Antibiotic-associated diarrhea
From IDWiki
Differential Diagnosis
- Clostridioides difficile
- Other microbes: Clostridium perfringens type A (food poisoning), Staphylococcus aureus, Salmonella enterica, and possible Candida albicans
- Direct effects on intestinal tract
- Erythromycin and clavulanate cause increased motility
- Penicillins may rarely cause a segmental colitis
- Effects on the fecal microbiota
- Decreased carbohydrate metabolism, leading to osmotic diarrhea
- Breakdown of primary bile acids, leading to secretory diarrhea
- Concomitant use of laxatives, antacids, contrast, lactose- or sorbitol-containing products, NSAIDs, antiarrhythmic drugs, and cholinergic drugs
