Organism
|
Distribution
|
Diseases
|
Treatment
|
Blastomyces species
|
eastern US and Canada, with some reported in Africa
|
pulmonary infection, verrucous skin lesions, osteomyelitis, CNS infection
|
itraconazole (with amphotericin B induction if severe)
|
Coccidioides species
|
southwestern US and parts of South and Central America
|
pulmonary infection, verrucous skin lesions, osteomyelitis, CNS infection
|
fluconazole (with amphotericin B and flucytosine induction if severe)
|
Histoplasma capsulatum
|
worldwide, including eastern North America, Central and South America, sub-Saharan Africa, and parts of Southeast Asia
|
pulmonary infection, CNS infection
|
itraconazole (with amphotericin B induction if severe)
|
Paracoccidioides brasiliensis
|
South America
|
pulmonary infection
|
itraconazole (with amphotericin B induction if severe)
|
Sporothrix schenckii
|
essentially worldwide
|
nodular lymphangitis
|
itraconazole
|
Talaromyces marneffei
|
Southeast Asia
|
disseminated (common in advanced HIV), pulmonary infection, abdominal abscess, skin lesions, osteomyelitis
|
amphotericin B induction followed by itraconazole
|