Tissue penetration of antimicrobials

Class	Antimicrobial	Blood	CNS	Urine	Prostate	Necrotic
Antibiotics: β-Lactams
Penicillins	β-lactamase inhibitors		–
	ampicillin		+			–
	piperacillin-tazobactam				+†
Cephalosporins	first-generation cephalosporins		–			–
	second-generation cephalosporins		–
	third-generation cephalosporins				+†
	cefepime					+
	ceftazidime		+			+
Cephamycins	cephamycins		–
	cefoxitin					–
Carbapenems	imipenem					+
Antibiotics: Non-β-Lactams
Aminoglycosides						–
Chloramphenicol	chloramphenicol					+
Fluoroquinolones			–?		+	+
Fosfomycin	fosfomycin				+
Lincosamides	clindamycin		–			+
Macrolides	macrolides		–		+
Nitrofurans	nitrofurantoin	–	–	+	–	–
Nitroimidazoles	metronidazole					+
Rifamycins	rifampin				+
Sulfonamides	trimethoprim-sulfamethoxazole				+
Tetracyclines	tetracyclines		–		+
	doxycycline				+	+
Antifungals
Azoles	fluconazole					+
Class	Antimicrobial	Blood	CNS	Urine	Prostate	Necrotic

• † if inflammation present