- Inhibits bacterial DNA-dependent RNA polymerase
- Never given alone due to rapid resistance
- Adverse effects include drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
- Avoid in liver failure
References
- ^ Gousia Dhhar, Jeanine McColl, Ian Kitai, Deborah M. Levy, Ruud H.J. Verstegen. Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection. Canadian Medical Association Journal. 2023;195(34):E1151-E1153. doi:10.1503/cmaj.230317.
