Neonatal HSV
From IDWiki
Background
- See also Herpes simplex virus
Pathophysiology
- Generally acquired at time of delivery, though 5-8% may be congenital
Clinical Presentation
- Incubation period 7 to 21 days post-partum, with range from birth to 6 weeks
- Spectrum of disease from cutaneous to disseminated
Disseminated disease
- 25% of cases
- Sepsis syndrome that predominantly affects the liver, lungs, and CNS
- May not have skin findings (25%)
- Usually presents in the first or second week of life
- Should be considered in sepsis without bacterial cause and with liver dysfunction or coagulopathy
Localized CNS disease
- 30% of cases
- Usually presents in the second or third week of life
- May not have cutaneous manifestations
- Can cause seizures
Skin, eye, and mouth disease
- 45% of cases
- Localized to skin, eyes, and/or mouth
- Usually presents in the first or second week of life
Prognosis
- 65% mortality if untreated
- With CNS disease, 80% have developmental problems
- Prognosis much better with isolated cutaneous disease
