Dapsone

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Background

  • Diamino-diphenyl sulfone

Indications

  • Second-line PJP prophylaxis (CD4 <200)
  • Rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae

Dosing

  • Dermatitis herpetiformis: Start at 50 mg PO daily, increase to 300 mg daily, or higher to achieve full control, reduce to minimum maintenance dosage as soon as possible
  • PJP prophylaxis (primary or secondary):
    • 100 mg PO once daily or in 2 divided doses as monotherapy
    • Continue until CD4 count >200 cells/mm3 for >3 months
  • PJP treatment: 100 mg PO once daily in combination with trimethoprim for 21 days