Exserohilum: Difference between revisions
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Exserohilum
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* An expert group has recommended [[Is treated by::voriconazole]] for CNS disease based on very little data |
* An expert group has recommended [[Is treated by::voriconazole]] for CNS disease based on very little data |
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{{DISPLAYTITLE:''Exserohilum'' |
{{DISPLAYTITLE:''Exserohilum''}} |
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[[Category:Dematiaceous molds]] |
[[Category:Dematiaceous molds]] |
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Latest revision as of 16:25, 17 February 2022
Clinical Manifestations
- Opportunistic pathogen in the immunocompromised, including aplastic anemia and HSCT
- Causes keratitis, sinusitis, cutaneous, and subcutaneous infections
- Of note, in 2012, it caused an outbreak of fungal meningitis associated with contaminated steroid injections (source was the compounding pharmacy)
Diagnosis
- Culture
- Colony: Growth is rapid and colonies are woolly and gray to black in color
- Microscopy
- Hyphae are septate and dematiaceous
- Conidiophores are geniculate as a result of sympodial development
- Conidia may be straight, curved or slightly bent and are distinguished by having prominent, protruding hila
Management
- Amphotericin B, itraconazole, voriconazole, and posaconazole have all been used successfully1
- An expert group has recommended voriconazole for CNS disease based on very little data
References
- ^ A. Katragkou, Z.-D. Pana, D. S. Perlin, D. P. Kontoyiannis, T. J. Walsh, E. Roilides. Exserohilum infections: Review of 48 cases before the 2012 United States outbreak. Medical Mycology. 2014;52(4):376-386. doi:10.1093/mmy/myt030.
