Antifungals: Difference between revisions

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*Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
*Mechanism: inhibit 14-alpha demethylase (aka. Cyp51p, encoded by Erg11 genes), which is required for synthesis of ergosterol from lanosterol, thus disrupting the cell wall.
*Examples
*Examples
**[[Fluconazole]]: Used as prophylaxis or treatment for [[Candida species]]
**[[Fluconazole]]: Used as prophylaxis or treatment for [[Candida]]
**[[Voriconazole]]: First-line treatment for [[invasive aspergillosis]]
**[[Voriconazole]]: First-line treatment for [[invasive aspergillosis]]
**[[Itraconazole]]
**[[Itraconazole]]

Latest revision as of 02:48, 8 February 2022

See also Antifungal spectrum of activity

Polyenes

  • Mechanism: bind to ergosterol in the cell membrane and create pores
  • Examples: Amphotericin B

Triazoles

Echinocandins

  • Mechanism: disrupt synthesis of beta-glucan in the cell wall by inhibiting 1,3-beta glucan synthase
  • Examples