Isavuconazole: Difference between revisions

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=== Spectrum of Activity ===
 
=== Spectrum of Activity ===
   
*Active against [[Candida]], [[Cryptococcus]], [[Aspergillus species]] including [[Aspergillus flavus]], [[Aspergillus fumigatus]], and [[Aspergillus niger]], and [[Mucorales]]
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*Active against [[Candida]], [[Cryptococcus]], [[Aspergillus]] including [[Aspergillus flavus]], [[Aspergillus fumigatus]], and [[Aspergillus niger]], and [[Mucorales]]
 
*Indications include {{#ask: [[Is treated by::isavuconazole]]}}
 
*Indications include {{#ask: [[Is treated by::isavuconazole]]}}
   

Revision as of 16:52, 27 January 2022

Background

Mechanism of Action

  • Azole antifungal that inhibits lanosterol 14-α demethylase in the peptidoglycan synthesis pathway

Spectrum of Activity

Dosing

  • Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily

Renal Dosing

  • No adjustment needed

Hepatic Dosing

  • No adjustment needed

Safety

Adverse Drug Reactions

  • Nausea, vomiting, diarrhea
  • Elevated liver enzymes
  • Hypokalemia

Drug-Drug Interactions