Amphotericin B: Difference between revisions

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*Causes renal dysfunction, among other things
  
*Causes renal dysfunction, among other things
   
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== Clinical Breakpoints ==
  +
{| class="wikitable"
  +
! rowspan="2" |Species
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! rowspan="2" |ECV (μg/mL)
  +
! colspan="4" |Breakpoints (μg/mL)
  +
! colspan="4" |Breakpoints (mm)
  +
|-
  +
!S
  +
!SDD
  +
!I
  +
!R
  +
!S
  +
!SDD
  +
!I
  +
!R
  +
|-
  +
|[[Candida albicans]]
  +
|2
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida dubliniensis]]
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida glabrata]]
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|2
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida guilliermondii]]
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida krusei]]
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|2
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida lusitaniae]]
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida parapsilosis]]
  +
|2
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Candida tropicalis]]
  +
|2
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Cryptococcus neoformans]]
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|0.5
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Cryptococcus gattii]]
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|0.5-1
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Aspergillus flavus]]
  +
|4
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Aspergillus fumigatus]]
  +
|2
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Aspergillus species]]
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|2
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|
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Aspergillus species]]
  +
|4
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|-
  +
|[[Aspergillus versicolor]]
  +
|2
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|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|}
 
[[Category:Polyenes]]
  
[[Category:Polyenes]]

Revision as of 21:18, 19 January 2021

  • Last choice of antifungal due to side effect profile, but effective
  • Binds to ergosterol in fungal cell membrane and creates pores that cause leakage of monovalent ions
  • Causes renal dysfunction, among other things

Clinical Breakpoints

Species ECV (μg/mL) Breakpoints (μg/mL) Breakpoints (mm)
S SDD I R S SDD I R
Candida albicans 2
Candida dubliniensis
Candida glabrata 2
Candida guilliermondii
Candida krusei 2
Candida lusitaniae
Candida parapsilosis 2
Candida tropicalis 2
Cryptococcus neoformans 0.5
Cryptococcus gattii 0.5-1
Aspergillus flavus 4
Aspergillus fumigatus 2
Aspergillus species 2
Aspergillus species 4
Aspergillus versicolor 2
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