Tissue penetration of antimicrobials: Difference between revisions

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Class	Antimicrobial	Blood	CNS	Urine	Prostate	Necrotic
Antibiotics: β-Lactams
Penicillins	β-lactamase inhibitors		–
	ampicillin		+			–
	piperacillin-tazobactam				+†
Cephalosporins	first-generation cephalosporins		–			–
	second-generation cephalosporins		–
	third-generation cephalosporins				+†
	cefepime					+
	ceftazidime		+			+
Cephamycins	cephamycins		–
Cephamycins	cefoxitin					–
Carbapenems	imipenem					+
Antibiotics: Non-β-Lactams
Aminoglycosides						–
Chloramphenicol	chloramphenicol					+
Fluoroquinolones			–?		+	+
Fosfomycin	fosfomycin				+
Lincosamides	clindamycin		–			+
Macrolides	macrolides		–		+
Nitrofurans	nitrofurantoin	–	–	+	–	–
Nitroimidazoles	metronidazole					+
Rifamycins	rifampin				+
Sulfonamides	trimethoprim-sulfamethoxazole				+
Tetracyclines	tetracyclines		–		+
Tetracyclines	doxycycline				+	+
Antifungals
Azoles	fluconazole					+
Class	Antimicrobial	Blood	CNS	Urine	Prostate	Necrotic

^ Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.

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+!Class
+!Antimicrobial
+!Blood
+!CNS
+!Urine
+!Prostate
+!Necrotic
 |}
-* † if inflammation present
+*† if inflammation present
 [[Category:Antimicrobials]]