Isavuconazole: Difference between revisions
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== Background == |
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=== Mechanism of Action === |
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* Azole antifungal that inhibits lanosterol 14-α demethylase in the peptidoglycan synthesis pathway |
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=== Spectrum of Activity === |
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*Active against [[Candida]], [[Cryptococcus]], [[Aspergillus species]] including [[Aspergillus flavus]], [[Aspergillus fumigatus]], and [[Aspergillus niger]], and [[Mucorales]] |
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*Indications include {{#ask: [[Is treated by::isavuconazole]]}} |
*Indications include {{#ask: [[Is treated by::isavuconazole]]}} |
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*Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily |
*Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily |
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=== Renal Dosing === |
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* No adjustment needed |
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=== Hepatic Dosing === |
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* No adjustment needed |
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== Safety == |
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=== Adverse Drug Reactions === |
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* Nausea, vomiting, diarrhea |
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* Elevated liver enzymes |
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* Hypokalemia |
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=== Drug-Drug Interactions === |
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* Increases levels of [[sirolimus]] and [[tacrolimus]] |
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* Increases levels of [[cyclosporine]] |
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* Contraindicated with [[carbamazepine]] |
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[[Category:Triazoles]] |
[[Category:Triazoles]] |
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Revision as of 10:59, 3 September 2020
Background
Mechanism of Action
- Azole antifungal that inhibits lanosterol 14-α demethylase in the peptidoglycan synthesis pathway
Spectrum of Activity
- Active against Candida, Cryptococcus, Aspergillus species including Aspergillus flavus, Aspergillus fumigatus, and Aspergillus niger, and Mucorales
- Indications include Chromoblastomycosis, Cladophialophora, Coccidioides immitis
Dosing
- Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily
Renal Dosing
- No adjustment needed
Hepatic Dosing
- No adjustment needed
Safety
Adverse Drug Reactions
- Nausea, vomiting, diarrhea
- Elevated liver enzymes
- Hypokalemia
Drug-Drug Interactions
- Increases levels of sirolimus and tacrolimus
- Increases levels of cyclosporine
- Contraindicated with carbamazepine
