Tissue penetration of antimicrobials: Difference between revisions
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! colspan="7" |Antibiotics: β-Lactams |
! colspan="7" |Antibiotics: β-Lactams |
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| rowspan="3" |Penicillins |
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|β-lactamase inhibitors |
|β-lactamase inhibitors |
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|[[piperacillin-tazobactam]] |
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|first-generation cephalosporins |
|first-generation cephalosporins |
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|second-generation cephalosporins |
|second-generation cephalosporins |
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|third-generation cephalosporins |
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|[[cephamycins]] |
|[[cephamycins]] |
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|Carbapenems |
|Carbapenems |
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|Chloramphenicol |
|Chloramphenicol |
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|[[clindamycin]] |
|[[clindamycin]] |
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|[[macrolides]] |
|[[macrolides]] |
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|Nitrofurans |
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|[[nitrofurantoin]] |
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|Nitroimidazoles |
|Nitroimidazoles |
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|[[tetracyclines]] |
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* † if inflammation present |
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[[Category:Antimicrobials]] |
[[Category:Antimicrobials]] |
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Revision as of 16:23, 24 August 2020
| Class | Antimicrobial | Blood | CNS | Urine | Prostate | Necrotic |
|---|---|---|---|---|---|---|
| Antibiotics: β-Lactams | ||||||
| Penicillins | β-lactamase inhibitors | – | ||||
| ampicillin | + | – | ||||
| piperacillin-tazobactam | +† | |||||
| Cephalosporins | first-generation cephalosporins | – | – | |||
| second-generation cephalosporins | – | |||||
| third-generation cephalosporins | +† | |||||
| cefepime | + | |||||
| ceftazidime | + | + | ||||
| Cephamycins | cephamycins | – | ||||
| cefoxitin | – | |||||
| Carbapenems | imipenem | + | ||||
| Antibiotics: Non-β-Lactams | ||||||
| Aminoglycosides | – | |||||
| Chloramphenicol | chloramphenicol | + | ||||
| Fluoroquinolones | –? | + | + | |||
| Lincosamides | clindamycin | – | + | |||
| Macrolides | macrolides | – | + | |||
| Nitrofurans | nitrofurantoin | – | – | + | – | – |
| Nitroimidazoles | metronidazole | + | ||||
| Rifamycins | rifampin | + | ||||
| Sulfonamides | sulfamethoxazole | – | ||||
| Tetracyclines | tetracyclines | – | + | |||
| doxycycline | + | |||||
| Antifungals | ||||||
| Azoles | fluconazole | + | ||||
- † if inflammation present
References
- ^ Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.
- ^ L. Brockhaus, D. Goldblum, L. Eggenschwiler, S. Zimmerli, C. Marzolini. Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics. Clinical Microbiology and Infection. 2019;25(11):1364-1369. doi:10.1016/j.cmi.2019.01.017.
