Rheumatologic serologies: Difference between revisions
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!Test |
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!Association |
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!Correlates with dz activity? |
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|ANA |
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|[[SLE]] |
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|No |
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|ANA (centromere pattern) |
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|[[CREST syndrome]], [[Systemic sclerosis|SSc]], PH |
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|Anti-Smith |
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|[[SLE]] (most specific) |
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|No |
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|Anti-dsDNA |
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|[[SLE]] |
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|Yes, especially renal disease |
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|Anti-histone |
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|[[Drug-induced lupus]] |
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|Anti-U1-RNP |
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| Mixed CTD |
|[[Mixed connective tissue disease|Mixed CTD]] |
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|Anti-Ro/SSA |
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|[[Sjögren syndrome]]<br />Neonatal heart block<br />[[Systemic lupus erythematosus|Subacute SLE]] |
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|Anti-La/SSB |
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|[[Sjögren syndrome]]<br />Sicca syndrome<br />[[Neonatal lupus|Neonatal SLE]] |
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|Anti-Scl-70 |
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| SSc and pulmonary fibrosis, dcSSc |
|[[Systemic sclerosis|SSc and pulmonary fibrosis]], [[Systemic sclerosis|dcSSc]] |
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|Anti-Jo-1 |
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|[[Polymyositis]]<br />[[Antisynthetase syndrome]] |
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|Anti-CCP |
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| RA (most specific) |
|[[Rheumatoid arthritis|RA]] (most specific) |
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|Anti-smooth muscle |
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|[[Autoimmune hepatitis]] |
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|Anti-PR3 (cANCA) |
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|[[Granulomatosis with polyangiitis|GPA]] |
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| GPA |
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|Anti-MPO (pANCA) |
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|[[Microscopic polyangiitis|MPA]] and [[Eosinophilic granulomatosis with polyangiitis|eGPA]] |
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| MPA and eGPA |
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Revision as of 19:24, 19 August 2020
| Test | Association | Correlates with dz activity? |
|---|---|---|
| ANA | SLE | No |
| ANA (centromere pattern) | CREST syndrome, SSc, PH | |
| Anti-Smith | SLE (most specific) | No |
| Anti-dsDNA | SLE | Yes, especially renal disease |
| Anti-histone | Drug-induced lupus | |
| Anti-U1-RNP | Mixed CTD | |
| Anti-Ro/SSA | Sjögren syndrome Neonatal heart block Subacute SLE |
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| Anti-La/SSB | Sjögren syndrome Sicca syndrome Neonatal SLE |
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| Anti-Scl-70 | SSc and pulmonary fibrosis, dcSSc | |
| Anti-Jo-1 | Polymyositis Antisynthetase syndrome |
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| Anti-CCP | RA (most specific) | |
| Anti-smooth muscle | Autoimmune hepatitis | |
| Anti-PR3 (cANCA) | GPA | |
| Anti-MPO (pANCA) | MPA and eGPA |
References
- ^ B. Hervier, M. Rimbert, F. Colonna, M. A. Hamidou, M. Audrain. Clinical significance of anti-Ro/SSA-52 kDa antibodies--a retrospective monocentric study. Rheumatology. 2009;48(8):964-967. doi:10.1093/rheumatology/kep145.
