Hemolytic-uremic syndrome: Difference between revisions

Revision as of 11:28, 15 August 2020

Typical HUS is a Thrombotic microangiopathy with prominent renal failure traditionally associated with Shiga toxin-producing Escherichia coli infection, especially enterohemorrhagic E. coli O157:H7
Difference pathophysiology and treatment from atypical hemolytic-uremic syndrome

Typical HUS is caused by Shiga toxin from enterohemorrhagic Escherichia coli (e.g. O157:H7)
Toxin is absorbed systemically, causing platelet activation and aggregation

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-== Background ==
+==Background==
-* [[Thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli''
+*Typical HUS is a [[Thrombotic microangiopathy]] with prominent renal failure traditionally associated with Shiga toxin-producing [[Escherichia coli]] infection, especially enterohemorrhagic ''E. coli'' O157:H7
-* Much more common in pediatric patients, followed by elderly patients
+*Difference pathophysiology and treatment from [[atypical hemolytic-uremic syndrome]]
+=== Pathophysiology ===
+* Typical HUS is caused by Shiga toxin from enterohemorrhagic [[Escherichia coli]] (e.g. O157:H7)
+* Toxin is absorbed systemically, causing platelet activation and aggregation
+=== Risk Factors ===
+* Younger age
+* Exposure to antibiotics
+* Increased WBC count
+* Vomiting
+* Prolonged diarrhea
+* Presence of ''stx2a'' and ''eae'' genes
+== Clinical Manifestations ==
+* A few days of bloody diarrhea
+* Progression of [[hemolytic anemia]], [[thrombocytopenia]], and severe [[AKI]]
+== Management ==
+* Supportive
 [[Category:Hematology]]