Hepatitis E virus: Difference between revisions
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== Clinical Manifestations == |
== Clinical Manifestations == |
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* Incubation period of about 4 to 6 weeks |
* Incubation period of about [[Usual incubation period::4 to 6 weeks]] |
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* Flu-like prodrome lasting 1 to 10 days with a low-grade fever, followed by hepatitis |
* Flu-like prodrome lasting 1 to 10 days with a low-grade [[Causes::fever]], followed by [[Causes::hepatitis]] |
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* May develop pale stools, dark urine, and jaundice |
* May develop [[Causes::pale stools]], [[Causes::dark urine]], and [[Causes::jaundice]] |
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* Hepatomegaly and sometimes splenomegaly |
* [[Causes::Hepatomegaly]] and sometimes [[splenomegaly]] |
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** Cholestasis more common in pregnant women |
** [[Cholestasis]] more common in pregnant women |
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* Liver enzyme abnormalities, over 1000 initially, and hyperbilirubinemia |
* Liver enzyme abnormalities, over 1000 initially, and [[Causes::hyperbilirubinemia]] |
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* Can progress to fulminant hepatitis |
* Can progress to fulminant hepatitis |
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* Particularly high mortality rate in pregnant women (25% in third trimester) |
* Particularly high mortality rate in pregnant women (25% in third trimester) |
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Revision as of 13:41, 5 August 2020
Background
Microbiology
- Member of the Hepeviridae family of RNA viruses
- Gour genotypes, g1 through g4
Epidemiology
- g1 and g2 are more common in developing countries
- Cause epidemic hepatitis
- Transmitted fecal-orally
- Associated with contaminated water and poor sanitation
- g3 and g4 more common in the North America and Europe
- Zoonoses associated with pigs; humans are incidental hosts
- Most severe infections in pregnant women
Clinical Manifestations
- Incubation period of about 4 to 6 weeks
- Flu-like prodrome lasting 1 to 10 days with a low-grade fever, followed by hepatitis
- May develop pale stools, dark urine, and jaundice
- Hepatomegaly and sometimes splenomegaly
- Cholestasis more common in pregnant women
- Liver enzyme abnormalities, over 1000 initially, and hyperbilirubinemia
- Can progress to fulminant hepatitis
- Particularly high mortality rate in pregnant women (25% in third trimester)
