Jaundice
From IDWiki
Etiologies
Unconjugated Hyperbilirubinemia
- Overproduction: hemolysis, Wilson disease, extravasation, shunt yperbilirubinemia
- Reduced uptake: portosystemic shunt, drugs, Gilbert syndrome
- Conjugation defect
- Acquired: neonatal, maternal milk, Lucy-Driscoll, hyperthyroidism, chronic persistent hepatitis, advanced cirrhosis
- Inherited: Crigler-Najjar syndrome, Gilbert syndrome
Conjugated or Combined Hyperbilirubinemia
- Intrahepatic cholestasis: PBC, PSC, viral hepatitis, progressive familial intrahepatis cholestasis, intrahepatic cholestasis of pregnancy, total parenteral nutrition, post-operative
- Drugs and toxins: alcoholic hepatitis, corticosteroids, chlorpromazine, some herbal medications, arsenic
- Infiltrative diseases, including amyloidosis, lymphoma, sarcoidosis, tuberculosis
- Sickle cell crisis
- Extrahepatic cholestasis: HIV cholangiopathy, choledocholithiasis, tumours, PSC, pancreatitis, strictures
- Some parasites: Ascaris lumbricoides, liver flukes
- Hepatocellular injury
- Defects in canalicular extretion or sinusoidal re-uptake: Dubin-Johnson syndrome, Rotor syndrome
