Pemphigoid gestationis: Difference between revisions

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== Epidemiology ==
== Background ==


===Epidemiology===
* 1 in 50,000 pregnancies


*1 in 50,000 pregnancies
== Clinical Manifestations ==


==Clinical Manifestations==
* Very itchy bullous or vesicular rash
* Typically starts periumbilically and spreads
* Starts in the second half of pregnancy, may flare post-partum


*Very itchy [[Bullous rash|bullous]] or [[vesicular rash]]
== Diagnosis ==
*Typically starts periumbilically and spreads
*Starts in the second half of pregnancy, may flare post-partum


==Diagnosis==
* Skin biopsy


*Skin biopsy
== Management ==


==Management==
* Prednisolone 0.5 mg/kg/d into the postpartum period, then titrate down
** May flare post-partum
* Second-line is azathioprine


*[[Is treated by::Prednisolone]] 0.5 mg/kg/d into the postpartum period, then titrate down
== Prognosis and Complications ==
**May flare post-partum
*Second-line is [[azathioprine]]


==Prognosis and Complications==
* 10% risk of neonatal pemphigoid

* Associated with other autoimmune disorders
*10% risk of [[neonatal pemphigoid]]
*Associated with other autoimmune disorders


[[Category:Dermatology]]
[[Category:Dermatology]]

Latest revision as of 02:11, 3 August 2020

Background

Epidemiology

  • 1 in 50,000 pregnancies

Clinical Manifestations

  • Very itchy bullous or vesicular rash
  • Typically starts periumbilically and spreads
  • Starts in the second half of pregnancy, may flare post-partum

Diagnosis

  • Skin biopsy

Management

  • Prednisolone 0.5 mg/kg/d into the postpartum period, then titrate down
    • May flare post-partum
  • Second-line is azathioprine

Prognosis and Complications