Clostridium septicum: Difference between revisions

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Clostridium septicum
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* Aggressive surgical debridement, possibly including amputation
* Aggressive surgical debridement, possibly including amputation
* Broad-spectrum antibiotics for [[necrotizing fasciitis]] are indicated until the microbiologic diagnosis is confirmed
* Broad-spectrum antibiotics for [[necrotizing fasciitis]] are indicated until the microbiologic diagnosis is confirmed
* First-line antimicrobials are [[Is treated by::penicillin]] plus [[Is treated by::clindamycin]]
* First-line antimicrobials are [[Is treated by::penicillin]] 2-4 million units IV q4h plus [[Is treated by::clindamycin]] 600-900 mg IV q6h


{{DISPLAYTITLE:''Clostridium septicum''}}
{{DISPLAYTITLE:''Clostridium septicum''}}

Revision as of 21:20, 13 April 2020

Background

Microbiology

Risk factors

  • Associated with colon cancer or neutropenia
  • Diabetes also a risk factor

Clinical Presentation

  • Can cause bacteremia and non-traumatic myonecrosis
  • Clinical presentation is typically fulminant sepsis, which very high mortality

Management

  • Aggressive surgical debridement, possibly including amputation
  • Broad-spectrum antibiotics for necrotizing fasciitis are indicated until the microbiologic diagnosis is confirmed
  • First-line antimicrobials are penicillin 2-4 million units IV q4h plus clindamycin 600-900 mg IV q6h