Pemphigus: Difference between revisions
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Created page with "* A group of rare, autoimmune blistering diseases * Includes pemphigus vulgaris and pemphigus foliaceus, and, much more rarely, paraneoplastic pemphigus and neonatal pemphigus Category:Dermatology" |
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* A group of rare, autoimmune blistering diseases |
* A group of rare, autoimmune blistering diseases |
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* Includes [[pemphigus vulgaris]] and [[pemphigus foliaceus]], and, much more rarely, [[paraneoplastic pemphigus]] and [[neonatal pemphigus]] |
* Includes [[pemphigus vulgaris]] and [[pemphigus foliaceus]], and, much more rarely, [[paraneoplastic pemphigus]] and [[neonatal pemphigus]] |
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{| class="wikitable" |
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!Disease |
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!Frequency |
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!Clinical Manifestations |
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!Diagnostic Clues |
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|[[Pemphigus vulgaris]] |
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|60-90% |
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|Almost universal mucosal involvement, mostly oropharyngeal, nasal, and genital |
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|Mucosal lesions, Nikosly sign, positive direct immunofluoresnence |
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|- |
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|[[Pemphigus foliaceus]] |
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|10-30% |
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|Crusted erosions, erythema, scales, mainly in seborrheic areas, and lacks mucosal involvement |
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|Crusted erosions, no mucosal lesions, Nikolsky sign, positive direct immunofluoresncence |
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|- |
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|[[Paraneoplastic pemphigus]] |
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|5% |
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|Severe stomatitis involving tongue and vermilion, erythema multiforme-like and lichenoid skin lesions, associated with leukemia and lymphoma |
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|Severe stomatitis, presence of malignancy, dyskeratosis and interface dermatitis |
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|[[IgA pemphigus]] |
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|3% |
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|Flaccid pustules, annular erosions, crusts, and erythematous plaques |
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|Pustules, staining of intercellular IgA in the epithelium by direct immunofluorescence |
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== Further Reading == |
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* Pemphigus. ''Lancet''. 2019 Sep 7;394(10201):882-894. doi: [https://doi.org/10.1016/S0140-6736(19)31778-7 10.1016/S0140-6736(19)31778-7] |
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[[Category:Dermatology]] |
[[Category:Dermatology]] |
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Latest revision as of 01:35, 7 January 2026
- A group of rare, autoimmune blistering diseases
- Includes pemphigus vulgaris and pemphigus foliaceus, and, much more rarely, paraneoplastic pemphigus and neonatal pemphigus
| Disease | Frequency | Clinical Manifestations | Diagnostic Clues |
|---|---|---|---|
| Pemphigus vulgaris | 60-90% | Almost universal mucosal involvement, mostly oropharyngeal, nasal, and genital | Mucosal lesions, Nikosly sign, positive direct immunofluoresnence |
| Pemphigus foliaceus | 10-30% | Crusted erosions, erythema, scales, mainly in seborrheic areas, and lacks mucosal involvement | Crusted erosions, no mucosal lesions, Nikolsky sign, positive direct immunofluoresncence |
| Paraneoplastic pemphigus | 5% | Severe stomatitis involving tongue and vermilion, erythema multiforme-like and lichenoid skin lesions, associated with leukemia and lymphoma | Severe stomatitis, presence of malignancy, dyskeratosis and interface dermatitis |
| IgA pemphigus | 3% | Flaccid pustules, annular erosions, crusts, and erythematous plaques | Pustules, staining of intercellular IgA in the epithelium by direct immunofluorescence |
Further Reading
- Pemphigus. Lancet. 2019 Sep 7;394(10201):882-894. doi: 10.1016/S0140-6736(19)31778-7
