Aztreonam: Difference between revisions
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Created page with "== Background == * The only drug in the monobactam class of monocyclic ß-lactam antibiotic * Originally isolated from Chromobacterium violaceum * Spectrum includes gram-negative aerobic bacteria ** Of special important, oftenn effective again ESBL-containing organisms, including metallo-ß-lactamases == Dosing == * UTI: 500 to 1000 mg IV every 8 to 12 hours * Moderately severe infections: 1 to 2 g IV every 8 to 12 hours * Severe or life-threatening infect..." |
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** Maximum daily dose is 8 g per day |
** Maximum daily dose is 8 g per day |
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* [[Pseudomonas aeruginosa]]: 2 g IV every 6 to 8 hours |
* [[Pseudomonas aeruginosa]]: 2 g IV every 6 to 8 hours |
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* Adjunctive, with [[ceftazidime-avibactam]]: 2 g IV every 8 hours, run in over 3 hours, ideally concurrently with the [[ceftazidime-avibactam]] |
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=== Renal Dosing === |
=== Renal Dosing === |
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Latest revision as of 16:59, 22 November 2025
Background
- The only drug in the monobactam class of monocyclic ß-lactam antibiotic
- Originally isolated from Chromobacterium violaceum
- Spectrum includes gram-negative aerobic bacteria
- Of special important, oftenn effective again ESBL-containing organisms, including metallo-ß-lactamases
Dosing
- UTI: 500 to 1000 mg IV every 8 to 12 hours
- Moderately severe infections: 1 to 2 g IV every 8 to 12 hours
- Severe or life-threatening infections: 2 g IV every 6 to 8 hours
- Maximum daily dose is 8 g per day
- Pseudomonas aeruginosa: 2 g IV every 6 to 8 hours
- Adjunctive, with ceftazidime-avibactam: 2 g IV every 8 hours, run in over 3 hours, ideally concurrently with the ceftazidime-avibactam
Renal Dosing
- CrCl 10-30: 1 to 2 g IV load, followed by 50% of usual dose
- CrCl <10 and IHD: 500 mg to 2 g IV load, followed by 25% of usual dose
- IHD: in addition to above, also 12.5% of usual dose after each run of hemodialysis
