Common variable immune deficiency: Difference between revisions
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Created page with "== Clinical Manifestations == * Recurrent sinopulmonary infections * Chronic diarrhea, including IBD-like disease * Can have concurrent autoimmune disease, including ITP, AIHA, rheumatoid arthritis, pernicious anemia, autoimmune thyroiditis, and vitiligo * Can have signs and symptoms of allergic rhinitis and asthma * Can have splenomegaly and lymphadenopathy * Increased risk of non-Hodgkin lymphoma == Differential Diagnosis == * Primary hyp..." |
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== Clinical Manifestations == |
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* Recurrent sinopulmonary infections |
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* Chronic diarrhea, including IBD-like disease |
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* Can have concurrent autoimmune disease, including [[ITP]], [[AIHA]], [[rheumatoid arthritis]], [[pernicious anemia]], [[autoimmune thyroiditis]], and [[vitiligo]] |
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* Can have signs and symptoms of allergic rhinitis and asthma |
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* Can have splenomegaly and lymphadenopathy |
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* Increased risk of [[non-Hodgkin lymphoma]] |
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== Differential Diagnosis == |
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* Primary hypogammaglobulinemia |
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** IgG subclass deficiency |
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** Hyperimmunoglobulin M syndrome |
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* Secondary hypogammaglobulinemia |
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** Drugs, including [[rituximab]], [[CAR-T]], [[BiTE]], long-term [[corticosteroids]], certain antiseizure medications, cytotoxic chemotherapy |
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** Malignancy, including [[CLL]], [[lymphoma]], [[multiple myeloma]], and [[Waldenström macroglobulinemia]] |
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** Thymoma with hypogammaglobulinemia ([[Good syndrome]]) |
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== Diagnosis == |
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* Over the age of 4 years |
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* All of the following: |
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** Low IgA and/or IgM |
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** Poor or absent response to immunization |
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** Absence of other immunodeficiency |
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Latest revision as of 20:32, 6 October 2025
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