Posaconazole: Difference between revisions

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(added EUCAST ECOFFs and breakpoints)
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! rowspan="2" |ECV (μg/mL)
 
! rowspan="2" |ECV (μg/mL)
 
! colspan="4" |Breakpoints (μg/mL)
 
! colspan="4" |Breakpoints (μg/mL)
! colspan="4" |Breakpoints (mm)
 
 
|-
 
|-
 
!S
 
!S
!SDD
 
 
!I
 
!I
!R
 
!S
 
 
!SDD
 
!SDD
!I
 
 
!R
 
!R
 
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|0.06
 
|0.06
 
|≤0.06
 
|≤0.06
 
| colspan="2" rowspan="9" |
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|≥0.12
 
|≥0.12
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|[[Candida dubliniensis]]
 
|[[Candida dubliniensis]]
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|[[Candida glabrata]]
 
|[[Candida glabrata]]
 
|2
 
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|[[Candida guilliermondii]]
 
|[[Candida guilliermondii]]
 
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|[[Candida kefyr]]
 
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|[[Candida krusei]]
 
|[[Candida krusei]]
 
|0.5
 
|0.5
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|[[Candida lusitaniae]]
 
|[[Candida lusitaniae]]
 
|0.12
 
|0.12
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|0.25
 
|0.25
 
|≤0.06
 
|≤0.06
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|≥0.12
 
|≥0.12
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|
 
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|-
 
|-
 
|[[Candida tropicalis]]
 
|[[Candida tropicalis]]
 
|0.12
 
|0.12
 
|≤0.06
 
|≤0.06
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|≥0.12
 
|≥0.12
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|[[Cryptococcus neoformans]]
 
|[[Cryptococcus neoformans]]
 
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| colspan="8" rowspan="2" |
+
| colspan="4" rowspan="2" |
 
|-
 
|-
 
|[[Cryptococcus gattii]]
 
|[[Cryptococcus gattii]]
 
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|-
  +
|[[Aspergillus flavus]]
  +
|0.5
  +
|—
  +
| colspan="2" rowspan="5" |
  +
|—
 
|-
  +
|[[Aspergillus fumigatus]]
  +
|0.25
  +
|≤0.125
  +
|>0.25
 
|-
  +
|[[Aspergillus nidulans]]
  +
|0.5
  +
|—
  +
|—
 
|-
  +
|[[Aspergillus niger]]
  +
|0.5
  +
|—
  +
|—
 
|-
  +
|[[Aspergillus terreus]]
  +
|0.25
  +
|≤0.125
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|>0.25
 
|}
 
|}
   

Revision as of 09:05, 22 October 2024

Therapeutic Drug Monitoring

  • Measure trough 7 days after starting or adjusting dose, or adjusting interacting medications, or concerns of poor adherence or absorption
  • For prophylaxis, target trough >0.7 mg/L, or random level 0.35 mg/L 48 h after starting therapy
  • For treatment, target trough >1 mg/L

Clinical Breakpoints

Species ECV (μg/mL) Breakpoints (μg/mL)
S I SDD R
Candida albicans 0.06 ≤0.06 ≥0.12
Candida dubliniensis
Candida glabrata 2
Candida guilliermondii 0.5
Candida kefyr 0.25
Candida krusei 0.5
Candida lusitaniae 0.12
Candida parapsilosis 0.25 ≤0.06 ≥0.12
Candida tropicalis 0.12 ≤0.06 ≥0.12
Cryptococcus neoformans
Cryptococcus gattii
Aspergillus flavus 0.5
Aspergillus fumigatus 0.25 ≤0.125 >0.25
Aspergillus nidulans 0.5
Aspergillus niger 0.5
Aspergillus terreus 0.25 ≤0.125 >0.25

Safety

Adverse Events

  • Liver toxicity
    • Generally transient and asymptomatic and self-limited
    • See also LiverTox