Clostridium septicum: Difference between revisions

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Clostridium septicum
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== Background ==
==Background==
=== Microbiology ===
===Microbiology===
* [[Stain::Gram-positive]] [[Shape::bacillus]]
* Member of the genus ''[[Clostridium species|Clostridium]]''
* Produces alpha toxin


*[[Stain::Gram-positive]] [[Shape::bacillus]]
=== Risk factors ===
*Member of the genus ''[[Clostridium species|Clostridium]]''
* Associated with colon cancer or neutropenia
*Produces alpha toxin, which lyses neutrophils
* Diabetes also a risk factor


===Risk factors===
== Clinical Manifestations ==
* Can cause bacteremia and non-traumatic myonecrosis
* Clinical presentation is typically fulminant sepsis, which very high mortality


*Associated with [[colon cancer]] or [[neutropenia]]
== Management ==
*[[Diabetes]] also a risk factor
* Aggressive surgical debridement, possibly including amputation

* Broad-spectrum antibiotics for [[necrotizing fasciitis]] are indicated until the microbiologic diagnosis is confirmed
==Clinical Manifestations==
* First-line antimicrobials are [[Is treated by::penicillin]] 2-4 million units IV q4h plus [[Is treated by::clindamycin]] 600-900 mg IV q6h

*Can cause bacteremia and non-traumatic myonecrosis
*Clinical presentation is typically fulminant sepsis, which very high mortality

==Management==

*Aggressive surgical debridement, possibly including amputation
*Broad-spectrum antibiotics for [[necrotizing fasciitis]] are indicated until the microbiologic diagnosis is confirmed
*First-line antimicrobials are [[Is treated by::penicillin]] 2-4 million units IV q4h plus [[Is treated by::clindamycin]] 600-900 mg IV q6h


{{DISPLAYTITLE:''Clostridium septicum''}}
{{DISPLAYTITLE:''Clostridium septicum''}}

Latest revision as of 13:49, 15 October 2020

Background

Microbiology

  • Gram-positive bacillus
  • Member of the genus Clostridium
  • Produces alpha toxin, which lyses neutrophils

Risk factors

Clinical Manifestations

  • Can cause bacteremia and non-traumatic myonecrosis
  • Clinical presentation is typically fulminant sepsis, which very high mortality

Management

  • Aggressive surgical debridement, possibly including amputation
  • Broad-spectrum antibiotics for necrotizing fasciitis are indicated until the microbiologic diagnosis is confirmed
  • First-line antimicrobials are penicillin 2-4 million units IV q4h plus clindamycin 600-900 mg IV q6h