Isavuconazole: Difference between revisions

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== Background ==

=== Mechanism of Action ===

* Azole antifungal that inhibits lanosterol 14-α demethylase in the peptidoglycan synthesis pathway

=== Spectrum of Activity ===

*Active against [[Candida]], [[Cryptococcus]], [[Aspergillus species]] including [[Aspergillus flavus]], [[Aspergillus fumigatus]], and [[Aspergillus niger]], and [[Mucorales]]
*Indications include {{#ask: [[Is treated by::isavuconazole]]}}
*Indications include {{#ask: [[Is treated by::isavuconazole]]}}


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*Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily
*Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily

=== Renal Dosing ===

* No adjustment needed

=== Hepatic Dosing ===

* No adjustment needed

== Safety ==

=== Adverse Drug Reactions ===

* Nausea, vomiting, diarrhea
* Elevated liver enzymes
* Hypokalemia

=== Drug-Drug Interactions ===

* Increases levels of [[sirolimus]] and [[tacrolimus]]
* Increases levels of [[cyclosporine]]
* Contraindicated with [[carbamazepine]]


[[Category:Triazoles]]
[[Category:Triazoles]]

Revision as of 10:59, 3 September 2020

Background

Mechanism of Action

  • Azole antifungal that inhibits lanosterol 14-α demethylase in the peptidoglycan synthesis pathway

Spectrum of Activity

Dosing

  • Isavuconazole 200 mg IV tid for 6 doses followed by 200 mg IV daily

Renal Dosing

  • No adjustment needed

Hepatic Dosing

  • No adjustment needed

Safety

Adverse Drug Reactions

  • Nausea, vomiting, diarrhea
  • Elevated liver enzymes
  • Hypokalemia

Drug-Drug Interactions