Tissue penetration of antimicrobials: Difference between revisions

Revision as of 15:03, 8 September 2020

Class	Antimicrobial	Blood	CNS	Urine	Prostate	Necrotic
Antibiotics: β-Lactams
Penicillins	β-lactamase inhibitors		–
	ampicillin		+			–
	piperacillin-tazobactam				+†
Cephalosporins	first-generation cephalosporins		–			–
	second-generation cephalosporins		–
	third-generation cephalosporins				+†
	cefepime					+
	ceftazidime		+			+
Cephamycins	cephamycins		–
Cephamycins	cefoxitin					–
Carbapenems	imipenem					+
Antibiotics: Non-β-Lactams
Aminoglycosides						–
Chloramphenicol	chloramphenicol					+
Fluoroquinolones			–?		+	+
Fosfomycin	fosfomycin				+
Lincosamides	clindamycin		–			+
Macrolides	macrolides		–		+
Nitrofurans	nitrofurantoin	–	–	+	–	–
Nitroimidazoles	metronidazole					+
Rifamycins	rifampin				+
Sulfonamides	trimethoprim-sulfamethoxazole				+
Tetracyclines	tetracyclines		–		+
Tetracyclines	doxycycline				+	+
Antifungals
Azoles	fluconazole					+
Class	Antimicrobial	Blood	CNS	Urine	Prostate	Necrotic

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+|-
+|Fosfomycin
+|[[fosfomycin]]
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 |Lincosamides
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 |-
 |Sulfonamides
-|[[sulfamethoxazole]]
+|[[trimethoprim-sulfamethoxazole]]
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+|-
+!Class
+!Antimicrobial
+!Blood
+!CNS
+!Urine
+!Prostate
+!Necrotic
 |}
-* † if inflammation present
+*† if inflammation present
 [[Category:Antimicrobials]]