Tissue penetration of antimicrobials: Difference between revisions

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!CNS
!CNS
!Urine
!Urine
!Prostate
!Necrotic
!Necrotic
|-
|-
! colspan="6" |Antibiotics
! colspan="7" |Antibiotics: β-Lactams
|-
|-
| rowspan="2" |Penicillins
| rowspan="2" |Penicillins
|β-lactamase inhibitors
|β-lactamase inhibitors
|
|
|NO
|–
⚫
|
|
|
|
|
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|[[ampicillin]]
|[[ampicillin]]
|
|
|YES
| +
|
|
|NO
|
|–
|-
|-
| rowspan="4" |Cephalosporins
| rowspan="4" |Cephalosporins
|first-generation cephalosporins
|first-generation cephalosporins
|
|
|NO
|–
|
|
|
|NO
|–
|-
|-
|second-generation cephalosporins
|second-generation cephalosporins
|
|
|NO
|–
|
|
|
|
|
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|
|
|
|
|YES
|
| +
|-
|-
|[[ceftazidime]]
|[[ceftazidime]]
|
|
|YES
| +
|
|
|YES
|
| +
|-
|-
| rowspan="2" |Cephamycins
| rowspan="2" |Cephamycins
|[[cephamycins]]
|[[cephamycins]]
|
|
|NO
|–
|
|
|
|
|
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|
|
|
|
|NO
|
|–
|-
|-
|Carbapenems
|Carbapenems
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|
|
|
|
|YES
|
| +
|-
! colspan="7" |Antibiotics: Non-β-Lactams
|-
|-
|Aminoglycosides
|Aminoglycosides
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|
|
|
|
|NO
|
|–
|-
⚫
|Chloramphenicol
|[[chloramphenicol]]
|
|
|
|
| +
|-
|-
|Fluoroquinolones
|Fluoroquinolones
|
|
|
|
|NO?
|–?
|
|
|YES
| +
| +
|-
|-
|Lincosamides
|Lincosamides
|[[clindamycin]]
|[[clindamycin]]
|
|
|NO
|–
|
|
|YES
|
| +
|-
|-
|Macrolides
|Macrolides
|[[macrolides]]
|
|
|–
|
|
|NO
| +
⚫
|
|
|
|-
|Nitrofurans
|[[nitrofurantoin]]
|–
|–
| +
|–
|–
|-
|-
|Nitroimidazoles
|Nitroimidazoles
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|
|
|
|
|YES
|
| +
|-
|-
|Rifamycins
⚫
| rowspan="2" |Tetracyclines
|[[tetracyclines]]
|[[rifampin]]
|
|
|NO
|
|
|
| +
|
|
|-
|-
|Sulfonamides
⚫
|[[doxycycline]]
|[[sulfamethoxazole]]
|
|
|
|
|
|
|YES
|–
|
|-
|-
⚫
| rowspan="2" |Tetracyclines
⚫
|Chloramphenicol
|[[chloramphenicol]]
|[[tetracyclines]]
|
|
|–
|
|
| +
|
|
|YES
|-
|-
⚫
|[[doxycycline]]
⚫
! colspan="6" |Antifungals
|
|
|
|
| +
|-
⚫
! colspan="7" |Antifungals
|-
|-
|Azoles
|Azoles
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|
|
|
|
|YES
|
| +
|}
|}
[[Category:Antimicrobials]]
[[Category:Antimicrobials]]

Revision as of 16:16, 24 August 2020

Class Antimicrobial Blood CNS Urine Prostate Necrotic
Antibiotics: β-Lactams
Penicillins β-lactamase inhibitors –
ampicillin + –
Cephalosporins first-generation cephalosporins – –
second-generation cephalosporins –
cefepime +
ceftazidime + +
Cephamycins cephamycins –
cefoxitin –
Carbapenems imipenem +
Antibiotics: Non-β-Lactams
Aminoglycosides –
Chloramphenicol chloramphenicol +
Fluoroquinolones –? + +
Lincosamides clindamycin – +
Macrolides macrolides – +
Nitrofurans nitrofurantoin – – + – –
Nitroimidazoles metronidazole +
Rifamycins rifampin +
Sulfonamides sulfamethoxazole –
Tetracyclines tetracyclines – +
doxycycline +
Antifungals
Azoles fluconazole +

References

  1. ^  Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.
  2. a b c d e f g h i j k l m n o p q r  L. Brockhaus, D. Goldblum, L. Eggenschwiler, S. Zimmerli, C. Marzolini. Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics. Clinical Microbiology and Infection. 2019;25(11):1364-1369. doi:10.1016/j.cmi.2019.01.017.
  3. a b  Takashi Suzuki, Toshihiko Uno, Guangming Chen, Yuichi Ohashi. Ocular distribution of intravenously administered micafungin in rabbits. Journal of Infection and Chemotherapy. 2008;14(3):204-207. doi:10.1007/s10156-008-0612-5.
  4. a b c d e f g h  Timothy Felton, Peter F. Troke, William W. Hope. Tissue Penetration of Antifungal Agents. Clinical Microbiology Reviews. 2014;27(1):68-88. doi:10.1128/cmr.00046-13.

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