Clostridium septicum: Difference between revisions
From IDWiki
Clostridium septicum
m (Text replacement - "Clinical Presentation" to "Clinical Manifestations") |
m (Text replacement - "[[Cellular shape::" to "[[Shape::") |
||
| Line 1: | Line 1: | ||
== Background == |
== Background == |
||
=== Microbiology === |
=== Microbiology === |
||
* [[Stain::Gram-positive]] [[ |
* [[Stain::Gram-positive]] [[Shape::bacillus]] |
||
* Member of the genus ''[[Clostridium species|Clostridium]]'' |
* Member of the genus ''[[Clostridium species|Clostridium]]'' |
||
* Produces alpha toxin |
* Produces alpha toxin |
||
Revision as of 14:57, 8 October 2020
Background
Microbiology
- Gram-positive bacillus
- Member of the genus Clostridium
- Produces alpha toxin
Risk factors
- Associated with colon cancer or neutropenia
- Diabetes also a risk factor
Clinical Manifestations
- Can cause bacteremia and non-traumatic myonecrosis
- Clinical presentation is typically fulminant sepsis, which very high mortality
Management
- Aggressive surgical debridement, possibly including amputation
- Broad-spectrum antibiotics for necrotizing fasciitis are indicated until the microbiologic diagnosis is confirmed
- First-line antimicrobials are penicillin 2-4 million units IV q4h plus clindamycin 600-900 mg IV q6h
