Clostridium septicum: Difference between revisions
From IDWiki
Clostridium septicum
m (Text replacement - "[[Has shape::" to "[[Cellular shape::") |
m (Text replacement - "Clinical Presentation" to "Clinical Manifestations") |
||
| Line 9: | Line 9: | ||
* Diabetes also a risk factor |
* Diabetes also a risk factor |
||
== Clinical |
== Clinical Manifestations == |
||
* Can cause bacteremia and non-traumatic myonecrosis |
* Can cause bacteremia and non-traumatic myonecrosis |
||
* Clinical presentation is typically fulminant sepsis, which very high mortality |
* Clinical presentation is typically fulminant sepsis, which very high mortality |
||
Revision as of 23:23, 14 July 2020
Background
Microbiology
- Gram-positive bacillus
- Member of the genus Clostridium
- Produces alpha toxin
Risk factors
- Associated with colon cancer or neutropenia
- Diabetes also a risk factor
Clinical Manifestations
- Can cause bacteremia and non-traumatic myonecrosis
- Clinical presentation is typically fulminant sepsis, which very high mortality
Management
- Aggressive surgical debridement, possibly including amputation
- Broad-spectrum antibiotics for necrotizing fasciitis are indicated until the microbiologic diagnosis is confirmed
- First-line antimicrobials are penicillin 2-4 million units IV q4h plus clindamycin 600-900 mg IV q6h
