Clostridium septicum: Difference between revisions
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Clostridium septicum
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== Background == |
== Background == |
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=== Microbiology === |
=== Microbiology === |
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* [[Stain::Gram-positive]] [[ |
* [[Stain::Gram-positive]] [[Cellular shape::bacillus]] |
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* Member of the genus ''[[Clostridium species|Clostridium]]'' |
* Member of the genus ''[[Clostridium species|Clostridium]]'' |
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* Produces alpha toxin |
* Produces alpha toxin |
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Revision as of 20:39, 6 July 2020
Background
Microbiology
- Gram-positive bacillus
- Member of the genus Clostridium
- Produces alpha toxin
Risk factors
- Associated with colon cancer or neutropenia
- Diabetes also a risk factor
Clinical Presentation
- Can cause bacteremia and non-traumatic myonecrosis
- Clinical presentation is typically fulminant sepsis, which very high mortality
Management
- Aggressive surgical debridement, possibly including amputation
- Broad-spectrum antibiotics for necrotizing fasciitis are indicated until the microbiologic diagnosis is confirmed
- First-line antimicrobials are penicillin 2-4 million units IV q4h plus clindamycin 600-900 mg IV q6h
