Peripheral neuropathy: Difference between revisions

Latest revision as of 00:59, 29 July 2020

Differential Diagnosis

Mononeuropathy
- Compression/injury
- Infiltration
- Mononeuritis
Mononeuritis multiplex
- Vasculitis
- Diabetes
Polyneuropathy
- Axonal injury
  - Neoplasm: carcinoma, lymphoma, MGUS
  - Infection: sepsis, chronic HIV, Lyme disease
  - Metabolic: diabetes, uremia
  - Vitamin deficiency: malabsorption
  - Drugs: cisplatin, taxanes, vincristine, isoniazid, nucleoside analogues
- Demyelinating
  - Guillain-Barré syndrome
  - Neoplasm: carcinoma, lymphoma, MGUS-IgM
  - Drugs: taxanes
  - Chronic inflammatory demyelinating polyradiculoneuropaty (CIDP)
Amyloid polyneuropathy
Charcot-Marie-Tooth disease
Critical illness neuropathy
Hypothyroidism

Investigations

Labs
- CBC, lytes, creatinine, glucose, ESR/CRP, SPEP, vitamin B12, ANA, TSH, urinalysis
- Based on presentation
  - EMG and nerve conduction
  - Nerve or muscle biopsy
  - LP
  - Lyme serology, HIV test, RPR/VDRL, HBV/HCV serology

@@ Line 1: / Line 1: @@
-== Differential Diagnosis ==
+==Differential Diagnosis==
-* Mononeuropathy
+*Mononeuropathy
-** Compression/injury
+**Compression/injury
-** Infiltration
+**Infiltration
-** Mononeuritis
+**Mononeuritis
-* Mononeuritis multiplex
+*[[Mononeuritis multiplex]]
-** Vasculitis
+**[[Vasculitis]]
-** Diabetes
+**[[Diabetes]]
-* Polyneuropathy
+*Polyneuropathy
-** Axonal injury
+**Axonal injury
-*** Neoplasm: carcinoma, lymphoma, MGUS
+***Neoplasm: [[carcinoma]], [[lymphoma]], [[MGUS]]
-*** Infection: sepsis, chronic HIV, Lyme disease
+***Infection: [[sepsis]], chronic [[HIV]], [[Lyme disease]]
-*** Metabolic: diabetes, uremia
+***Metabolic: [[diabetes]], [[uremia]]
-*** Vitamin deficiency: malabsorption
+***Vitamin deficiency: [[malabsorption]]
-*** Drugs: cisplatin, taxanes, vincristine, isoniazid, nucleoside analogues
+***Drugs: [[cisplatin]], [[taxanes]], [[vincristine]], [[isoniazid]], [[nucleoside analogues]]
-** Demyelinating
+**Demyelinating
-*** Guillain-Barre syndrome
+***[[Guillain-Barré syndrome]]
-*** Neoplasm: carcinoma, lymphoma, MGUS-IgM
+***Neoplasm: [[carcinoma]], [[lymphoma]], [[MGUS]]-IgM
-*** Drugs: taxanes
+***Drugs: [[taxanes]]
-*** Chronic inflammatory demyelinating polyradiculoneuropaty (CIDP)
+***[[Chronic inflammatory demyelinating polyradiculoneuropaty]] (CIDP)
-* Amyloid polyneuropathy
+*Amyloid polyneuropathy
-* Charcot-Marie-Tooth disease
+*[[Charcot-Marie-Tooth disease]]
-* Critical illness neuropathy
+*[[Critical illness neuropathy]]
-* Hypothyroidism
+*[[Hypothyroidism]]
-== Investigations ==
+==Investigations==
-* Labs
+*Labs
-** CBC, lytes, creatinine, glucose, ESR/CRP, SPEP, vitamin B12, ANA, TSH, urinalysis
+**CBC, lytes, creatinine, glucose, ESR/CRP, SPEP, vitamin B12, ANA, TSH, urinalysis
-** Based on presentation
+**Based on presentation
-*** EMG and nerve conduction
+***EMG and nerve conduction
-*** Nerve or muscle biopsy
+***Nerve or muscle biopsy
-*** LP
+***LP
-*** Lyme serology, HIV test, RPR/VDRL, HBV/HCV serology
+***Lyme serology, HIV test, RPR/VDRL, HBV/HCV serology
 [[Category:Neurology]]