Vertebral osteomyelitis: Difference between revisions

Revision as of 19:09, 13 October 2020

Background

Microbiology

Staphylococcus aureus
Other Gram-positive cocci, including viridans group streptococci, Streptococcus bovis, enterococci, Streptococcus agalactiae, group C and G streptococci
Less commonly, coagulase-negative staphylococci, Gram-negative bacilli, including Pseudomonas aeruginosa, and Candida species, especially in patients with indwelling lines or injection drug use
Tuberculosis
Brucella, in patients from endemic countries, can be as high as 25% of cases

Management

IV or highly bioavailable oral (metronidazole, fluoroquinolones, linezolid, TMP-SMX, clindamycin, and doxycycline/rifampin)
- Can double-cover Enterococcus with an aminoglycoside for 4 to 6 weeks
Duration: 6 weeks for most, but 3 months for Brucella

Brucella

Doxycycline/rifampin
Duration: 3 months

Prognosis

Cure rates are 70-90% with 6 weeks of antibiotics, and are not higher with longer durations (per a single RCT)
Poor prognosis is associated with multidisc disease, the presence of concomitant epidural abscess, lack of surgical therapy, infection with S. aureus, old age, or the presence of significant comorbidities

@@ Line 1: / Line 1: @@
-== Microbiology ==
+== Background ==
+===Microbiology===
-* ''Staphylococcus aureus''
-* ''Brucella'', in patients from endemic countries, can be as high as 25% of cases
+*[[Staphylococcus aureus]]
-== Management ==
+*Other [[Gram-positive cocci]], including [[viridans group streptococci]], [[Streptococcus bovis]], [[enterococci]], [[Streptococcus agalactiae]], group C and G [[streptococci]]
+*Less commonly, [[coagulase-negative staphylococci]], [[Gram-negative bacilli]], including [[Pseudomonas aeruginosa]], and [[Candida species]], especially in patients with indwelling lines or injection drug use
+*[[Tuberculosis]]
+*[[Brucella melitensis|Brucella]], in patients from endemic countries, can be as high as 25% of cases
+==Management==
-* IV or highly bioavailable oral (metronidazole, fluoroquinolones, linezolid, TMP-SMX, clindamycin, and doxycycline/rifampin)
-** Can double-cover ''Enterococcus'' with an aminoglycoside for 4 to 6 weeks
-* Duration: 6 weeks for most, but 3 months for ''Brucella''
-*
+*IV or highly bioavailable oral (metronidazole, fluoroquinolones, linezolid, TMP-SMX, clindamycin, and doxycycline/rifampin)
-=== ''Brucella'' ===
+**Can double-cover ''Enterococcus'' with an aminoglycoside for 4 to 6 weeks
+*Duration: 6 weeks for most, but 3 months for ''Brucella''
+*
+===''Brucella''===
-* Doxycycline/rifampin
-* Duration: 3 months
+*Doxycycline/rifampin
-== Prognosis ==
+*Duration: 3 months
+==Prognosis==
-* Cure rates are 70-90% with 6 weeks of antibiotics, and are ''not'' higher with longer durations (per a single RCT)
-* Poor prognosis is associated with multidisc disease, the presence of concomitant epidural abscess, lack of surgical therapy, infection with ''S. aureus'', old age, or the presence of significant comorbidities
+*Cure rates are 70-90% with 6 weeks of antibiotics, and are ''not'' higher with longer durations (per a single RCT)
+*Poor prognosis is associated with multidisc disease, the presence of concomitant epidural abscess, lack of surgical therapy, infection with ''S. aureus'', old age, or the presence of significant comorbidities
 [[Category:Bone and joint infections]]