Pseudomonas aeruginosa: Difference between revisions
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Pseudomonas aeruginosa
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* Oxidase-positive, non-fermenting Gram negative bacillus |
* Oxidase-positive, non-fermenting Gram negative bacillus |
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= Mechanisms of Resistance = |
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* Broad intrinsic and acquired antibiotic resistance |
* Broad intrinsic and acquired antibiotic resistance |
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* Plasmid sharing |
* Plasmid sharing |
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= Environment and Infections = |
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* Loves moist and wet environments |
* Loves moist and wet environments |
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** Especially common in cystic fibrosis |
** Especially common in cystic fibrosis |
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= Treatment = |
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* See [Antipseudomonal antibiotics](/Infectious Diseases/Basics/Antimicrobials/Antipseudomonal antibiotics.md) |
* See [Antipseudomonal antibiotics](/Infectious Diseases/Basics/Antimicrobials/Antipseudomonal antibiotics.md) |
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* Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection |
* Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection |
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[[Category:Gram-negative bacilli]] |
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Revision as of 03:39, 15 August 2019
Microbiology
- Oxidase-positive, non-fermenting Gram negative bacillus
Mechanisms of Resistance
- Broad intrinsic and acquired antibiotic resistance
- Membrane impermeability
- MexAB-OprM efflux pump
- Acquired mutations
- Inducible AmpC β-lactamase
- Plasmid sharing
Environment and Infections
- Loves moist and wet environments
- Causes healthcare-associated infections
- UTI, SSI, bacteremia, HAP, VAP
- Especially common in cystic fibrosis
Treatment
- See [Antipseudomonal antibiotics](/Infectious Diseases/Basics/Antimicrobials/Antipseudomonal antibiotics.md)
- Double coverage (ß-lactam + non-ß-lactam) in cases of severe infection in order to ensure activity against the infection
References
- ^ D. M. Livermore. Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?. Clinical Infectious Diseases. 2002;34(5):634-640. doi:10.1086/338782.
