Rifampin: Difference between revisions
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* Multiple |
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* Induces [[Induces::CYP2B6]], [[Induces::CYP2C8]], [[Induces::CYP2C9]], [[Induces::CYP2C19]], [[Induces::CYP2D6]], and [[Induces::CYP3A]] |
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* Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]] |
* Other antibiotics include [[clindamycin]], [[doxycycline]], [[linezolid]], [[moxifloxacin]], [[trimethoprim]], and [[fusidic acid]] |
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Revision as of 14:12, 23 September 2024
Background
- Inhibits bacterial DNA-dependent RNA polymerase
- Never given alone due to rapid resistance
Dosing
- As adjunct to fluoroquinolone for Staphylococcus aureus:
- Weight <60 kg: 600 mg p.o. daily
- Weight >60 kg: 450 mg p.o. twice daily
Safety
- Avoid in liver failure
Adverse Effects
- Orange or red discoloration of body fluids
- Drug-drug interactions, rash, hepatitis, influenza-like illness, neutropenia, and thrombocytopenia
- Drug-drug interactions
- Flu-like syndrome[1], a type III hypersensitivity reaction characterized by fevers, chills, myalgias, and arthalgias usually 1-4 hours (but up to 12 hours) after a dose, and lasts for 8 hours; if rechallenged, can develop hypotension and shock
Drug-Drug Interactions
- Multiple
- Induces CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP3A
- Other antibiotics include clindamycin, doxycycline, linezolid, moxifloxacin, trimethoprim, and fusidic acid
- ↑ Dhhar G, McColl J, Kitai I, Levy DM, Verstegen RHJ. Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection. CMAJ. 2023;195(34):E1151-E1153. DOI: 10.1503/cmaj.230317
