Clostridium septicum: Difference between revisions
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Clostridium septicum
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==Background== |
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===Microbiology=== |
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*[[Stain::Gram-positive]] [[Shape::bacillus]] |
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*Member of the genus ''[[Clostridium species|Clostridium]]'' |
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*Produces alpha toxin, which lyses neutrophils |
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===Risk factors=== |
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*[[Diabetes]] also a risk factor |
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==Clinical Manifestations== |
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*Can cause bacteremia and non-traumatic myonecrosis |
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*Clinical presentation is typically fulminant sepsis, which very high mortality |
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==Management== |
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*Aggressive surgical debridement, possibly including amputation |
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*Broad-spectrum antibiotics for [[necrotizing fasciitis]] are indicated until the microbiologic diagnosis is confirmed |
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*First-line antimicrobials are [[Is treated by::penicillin]] 2-4 million units IV q4h plus [[Is treated by::clindamycin]] 600-900 mg IV q6h |
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{{DISPLAYTITLE:''Clostridium septicum''}} |
{{DISPLAYTITLE:''Clostridium septicum''}} |
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Latest revision as of 13:49, 15 October 2020
Background
Microbiology
- Gram-positive bacillus
- Member of the genus Clostridium
- Produces alpha toxin, which lyses neutrophils
Risk factors
- Associated with colon cancer or neutropenia
- Diabetes also a risk factor
Clinical Manifestations
- Can cause bacteremia and non-traumatic myonecrosis
- Clinical presentation is typically fulminant sepsis, which very high mortality
Management
- Aggressive surgical debridement, possibly including amputation
- Broad-spectrum antibiotics for necrotizing fasciitis are indicated until the microbiologic diagnosis is confirmed
- First-line antimicrobials are penicillin 2-4 million units IV q4h plus clindamycin 600-900 mg IV q6h
