Clostridial toxic shock syndrome: Difference between revisions
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== Background == |
== Background == |
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* [[Toxic shock syndrome]] caused by [[Clostridium sordellii]] |
* [[Toxic shock syndrome]] caused by [[Clostridium sordellii]] (also [[Clostridium perfringens]]) |
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* Most commonly after spontaneous or therapeutic abortion |
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== Clinical Manifestations == |
== Clinical Manifestations == |
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* Tachycardia and hypotension |
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* Leukemoid reaction |
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* Often afebrile |
* Often afebrile |
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* [[Leukemoid reaction]], with a median peak of 90-100, and the degree of which predicts mortality |
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== Management == |
== Management == |
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Latest revision as of 14:34, 7 March 2023
Background
- Toxic shock syndrome caused by Clostridium sordellii (also Clostridium perfringens)
- Most commonly after spontaneous or therapeutic abortion
Clinical Manifestations
- Tachycardia and hypotension
- Often afebrile
- Hemoconcentration with high hematocrit and hemoglobin
- Capillary leak causing anasarca and effusions (pleural, pericardial, ascites)
- Leukemoid reaction, with a median peak of 90-100, and the degree of which predicts mortality
Management
- Fluid resuscitation
- Penicillin G 18-20 million units daily divided q4-6h
- Plus clindamycin 900 mg IV q8h for toxin production
