Rheumatoid factor: Difference between revisions
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== Background == |
== Background == |
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* General class of IgM antibodies to the Fc region of IgG |
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* Anti-IgG IgM antibody |
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*Most asymptomatic people with positive RF do ''not'' progress to [[rheumatoid arthritis]] |
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*Neither specific nor sensitive for [[RA]] |
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== Differential Diagnosis == |
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* Rheumatic disorders |
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** [[Rheumatoid arthritis]] (26-90%) |
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**[[Systemic lupus erythematosus]] (15-35%), [[Sjögren syndrome]] (75-95%), and [[mixed connective tissue disorder]] (50-60%) |
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** Type II and III [[cryoglobulinemia]] (40-100%) |
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** [[Polymyositis]] and [[dermatomyositis]] (5-10%) |
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* Chronic infections |
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** Bacterial [[endocarditis]] (25-50%) |
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** [[Hepatitis B]] and [[hepatitis C]] (20-75%) |
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** Other viruses, such as [[HIV]], [[Epstein-Barr virus]], and [[CMV]] |
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** Some parasites, including [[malaria]], [[schistosomiasis]], and [[toxoplasmosis]] |
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* Inflammatory disorders |
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** [[Cirrhosis]] (25%) |
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** [[Primary biliary cirrhosis]] (45-70%) |
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** [[Idiopathic pulmonary fibrosis]] (10-50%) |
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** [[Sarcoidosis]] (3-33%) |
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** [[Silicosis]] and [[asbestosis]] (30-50%) |
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* Malignancies |
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** B-cell disorders (5-25%) |
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* Normal aging |
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** ≥65 years of age (5-25%) |
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== Further Reading == |
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* Rheumatoid Factors: Clinical Applications. ''Dis Markers''. 2013;35(6):727–734. doi: [https://doi.org/10.1155/2013/726598 10.1155/2013/726598] |
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[[Category:Rheumatology]] |
[[Category:Rheumatology]] |
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Latest revision as of 10:39, 27 March 2022
Background
- General class of IgM antibodies to the Fc region of IgG
- Most asymptomatic people with positive RF do not progress to rheumatoid arthritis
- Neither specific nor sensitive for RA
Differential Diagnosis
- Rheumatic disorders
- Rheumatoid arthritis (26-90%)
- Systemic lupus erythematosus (15-35%), Sjögren syndrome (75-95%), and mixed connective tissue disorder (50-60%)
- Type II and III cryoglobulinemia (40-100%)
- Polymyositis and dermatomyositis (5-10%)
- Chronic infections
- Bacterial endocarditis (25-50%)
- Hepatitis B and hepatitis C (20-75%)
- Other viruses, such as HIV, Epstein-Barr virus, and CMV
- Some parasites, including malaria, schistosomiasis, and toxoplasmosis
- Inflammatory disorders
- Cirrhosis (25%)
- Primary biliary cirrhosis (45-70%)
- Idiopathic pulmonary fibrosis (10-50%)
- Sarcoidosis (3-33%)
- Silicosis and asbestosis (30-50%)
- Malignancies
- B-cell disorders (5-25%)
- Normal aging
- ≥65 years of age (5-25%)
Further Reading
- Rheumatoid Factors: Clinical Applications. Dis Markers. 2013;35(6):727–734. doi: 10.1155/2013/726598
