Endogenous fungal endophthalmitis: Difference between revisions
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(Created page with "== Management == === Tissue Penetration === * Penetration of antifungals into the vitreous is variable, though increases with inflammation * Amphotericin B has poor penetrat...") |
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==Management== |
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===Tissue Penetration=== |
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*Penetration of antifungals into the vitreous is variable, though increases with inflammation |
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*[[Amphotericin B]] has poor penetration into the vitreous, with liposomal better than non-liposomal |
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**It can be given intravitreally 5 to 10 μg of AmB-D as adjunctive therapy |
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*[[Flucytosine]] has excellent penetration |
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*Azoles |
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**[[Fluconazole]] has good penetration, reaching intravitreal levels of 70% those in plasma |
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**[[Voriconazole]] reaches 38% in non-inflamed eyes, and can also be given intravitreally up to 25 μg/mL |
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**Unclear other azoles |
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*Echinocandins have poor ocular penetration and are not recommended |
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[[Category:Eye infections]] |
[[Category:Eye infections]] |
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Latest revision as of 17:37, 5 April 2021
Management
Tissue Penetration
- Penetration of antifungals into the vitreous is variable, though increases with inflammation
- Amphotericin B has poor penetration into the vitreous, with liposomal better than non-liposomal
- It can be given intravitreally 5 to 10 μg of AmB-D as adjunctive therapy
- Flucytosine has excellent penetration
- Azoles
- Fluconazole has good penetration, reaching intravitreal levels of 70% those in plasma
- Voriconazole reaches 38% in non-inflamed eyes, and can also be given intravitreally up to 25 μg/mL
- Unclear other azoles
- Echinocandins have poor ocular penetration and are not recommended
