Penicillin-binding protein: Difference between revisions

Latest revision as of 12:46, 20 July 2023

A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure

	Class A							Class B										Class C
	A1	A2	A3	A4	A5	A6	A7	B1	B2	B3	B4	B5	B5	B6	B-like-I	B-like-II	B-like-III	Type-4	Type-5	Type-7	Type-AmpH
Gram-Negative Bacteria
Escherichia coli	PBP1a ponA	PBP1b ponB				PBP1c pbpC	MGT mgt		PHP2 pbpA	PHP3 ftsI								PBP4 dacB	PBP5, PHP6, PHP6b dacA, dacC, dacD	PBP7 pbpG	PBP4b, AmpH yefw, ampH
Neisseria gonorrhoeae	PBP1 ponA									PBP2 ftsI								PBP3 pbp3		PBP4 pbp4
Gram-Positive Bacteria
Staphylococcus aureus			PBP2 pbp2				MGT mgt	PBP2a mecA			PBP1 pbpA	PBP3 pbp3							PBP4 pbp4
Listeria monocytogenes			PBP1	PBP4				PBP			PBP2	PBP3							PBP5
Enterococcus faecalis			PBP1a	PBP2a	PBP1b			PBP4			PBP2	PBP2b							DacF
Streptococcus pneumoniae			PBP1a pbpA	PBP2a pbp2&	PBP1b pbp1b						PBP2x pvpX	PBP2b pbp2b							PBP3 pbp3
Other Bacteria
Mycobacterium tuberculosis				PBP1 ponA1			PBP1A (r) ponA2		PBPA pbpA		PBP2 pbpB					PBP-lipo Rv2864c		PBP4 Rv3627	PBP5 dacB1	PBP7 dacB2	PBP

PBP Mutations

Escherichia coli: PBP3 insert (YRIN/YRIK)
Klebsiella pneumoniae: PBP1, PBP2, and PBP3
Pseudomonas aeruginosa: PBP1 and PBP3
Acinetobacter baumannii: PHP3-H370Y, PBP3-Q488K and Y528H

Antibiotic Targets

MSSA
- Cefazolin: primarily PBP2, but all except PBP4
- Ertapenem: PBP1
- Cefaclor: PBP3
- Cefoxitin: PBP4

@@ Line 2: / Line 2: @@
 {| class="wikitable"
+! rowspan="2" |
-!
 ! colspan="7" |Class A
 ! colspan="10" |Class B
 ! colspan="4" |Class C
 |-
-!
 !A1
 !A2
@@ Line 34: / Line 33: @@
 |[[Escherichia coli]]
 |PBP1a
+''ponA''
 |PBP1b
+''ponB''
 |
 |
 |
 |PBP1c
+''pbpC''
 |MGT
+''mgt''
 |
 |PHP2
+''pbpA''
 |PHP3
+''ftsI''
 |
 |
@@ Line 51: / Line 56: @@
 |
 |PBP4
+''dacB''
 |PBP5, PHP6, PHP6b
+''dacA, dacC, dacD''
 |PBP7
+''pbpG''
 |PBP4b, AmpH
+''yefw, ampH''
 |-
 |[[Neisseria gonorrhoeae]]
 |PBP1
+''ponA''
 |
 |
 |
@@ Line 66: / Line 77: @@
 |
 |PBP2
+''ftsI''
 |
 |
@@ Line 74: / Line 86: @@
 |
 |PBP3
+''pbp3''
 |
 |PBP4
+''pbp4''
 |
 |-
@@ Line 84: / Line 98: @@
 |
 |PBP2
+''pbp2''
 |
 |
 |
 |MGT
+''mgt''
 |PBP2a
+''mecA''
 |
 |
 |PBP1
+''pbpA''
 |PBP3
+''pbp3''
 |
 |
@@ Line 100: / Line 119: @@
 |
 |PBP4
+''pbp4''
 |
 |
 |-
@@ Line 153: / Line 174: @@
 |
 |PBP1a
+''pbpA''
 |PBP2a
+''pbp2&''
 |PBP1b
+''pbp1b''
 |
 |
@@ Line 161: / Line 185: @@
 |
 |PBP2x
+''pvpX''
 |PBP2b
+''pbp2b''
 |
 |
@@ Line 168: / Line 194: @@
 |
 |
+|PBP3
-|PBP3s
+''pbp3''
 |
 |
@@ Line 182: / Line 209: @@
 |
 |
+|PBP1A (r)
+''ponA2''
 |
+|PBPA
+''pbpA''
 |
+|PBP2
+''pbpB''
 |
 |
 |
 |
+|PBP-lipo
+''Rv2864c''
 |
+|PBP4
-|
+''Rv3627''
-|
+|PBP5
-|
+''dacB1''
-|
+|PBP7
-|
+''dacB2''
-|
-|
+|PBP
-|
 |}
-<br />
+== PBP Mutations ==
+* [[Escherichia coli]]: PBP3 insert (YRIN/YRIK)
+* [[Klebsiella pneumoniae]]: PBP1, PBP2, and PBP3
+* [[Pseudomonas aeruginosa]]: PBP1 and PBP3
+* [[Acinetobacter baumannii]]: PHP3-H370Y, PBP3-Q488K and Y528H
+== Antibiotic Targets ==
+* MSSA
+** Cefazolin: primarily PBP2, but all except PBP4
+** Ertapenem: PBP1
+** Cefaclor: PBP3
+** Cefoxitin: PBP4
 [[Category:Infectious diseases]]
 [[Category:Microbiology]]