Cefiderocol: Difference between revisions
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(Created page with "== Background == === Mechanism of Activity === * Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin === Spectrum of Activity === * Acti...") |
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+ | ==Background== |
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+ | ===Mechanism of Activity=== |
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+ | *Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin |
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+ | ===Spectrum of Activity=== |
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+ | *Active against all Ambler class beta-lactamases, including carbapenemases |
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+ | *Active against [[Acinetobacter]], [[Enterobacterales]], [[Pseudomonas]], [[Burkholderia]], and [[Stenotrophomonas]] |
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+ | *Not active against Gram-positive bacteria |
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| + | == Dosing == |
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| + | * Carbapenem-resistant [[Enterobacterales]], multi-drug-resistant [[Pseudomonas aeruginosa]], carbapenem-resistant [[Acinetobacter baumannii]], and [[Stenotrophomonas maltophila]] 2 g IV q8h, infused over 3 hours |
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| + | [[Category:Siderophore cephalosporins]] |
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Latest revision as of 15:04, 24 November 2021
Background
Mechanism of Activity
- Uses siderophore iron transport system to enter cell, where it acts as a cephalosporin
Spectrum of Activity
- Active against all Ambler class beta-lactamases, including carbapenemases
- Active against Acinetobacter, Enterobacterales, Pseudomonas, Burkholderia, and Stenotrophomonas
- Not active against Gram-positive bacteria
Dosing
- Carbapenem-resistant Enterobacterales, multi-drug-resistant Pseudomonas aeruginosa, carbapenem-resistant Acinetobacter baumannii, and Stenotrophomonas maltophila 2 g IV q8h, infused over 3 hours
