Penicillin-binding protein: Difference between revisions

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* A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure
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*A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure
  +
  +
{| class="wikitable"
  +
! rowspan="2" |
  +
! colspan="7" |Class A
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! colspan="10" |Class B
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! colspan="4" |Class C
  +
|-
  +
!A1
  +
!A2
  +
!A3
  +
!A4
  +
!A5
  +
!A6
  +
!A7
  +
!B1
  +
!B2
  +
!B3
  +
!B4
  +
!B5
  +
!B5
  +
!B6
  +
!B-like-I
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!B-like-II
  +
!B-like-III
  +
!Type-4
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!Type-5
  +
!Type-7
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!Type-AmpH
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|-
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! colspan="22" |Gram-Negative Bacteria
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|-
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|[[Escherichia coli]]
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|PBP1a
  +
''ponA''
  +
|PBP1b
  +
''ponB''
  +
|
  +
|
  +
|
  +
|PBP1c
  +
''pbpC''
  +
|MGT
  +
''mgt''
  +
|
  +
|PHP2
  +
''pbpA''
  +
|PHP3
  +
''ftsI''
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|PBP4
  +
''dacB''
  +
|PBP5, PHP6, PHP6b
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''dacA, dacC, dacD''
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|PBP7
  +
''pbpG''
  +
|PBP4b, AmpH
  +
''yefw, ampH''
  +
|-
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|[[Neisseria gonorrhoeae]]
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|PBP1
  +
''ponA''
  +
|
  +
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|PBP2
  +
''ftsI''
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|PBP3
  +
''pbp3''
  +
|
  +
|PBP4
  +
''pbp4''
  +
|
  +
|-
  +
! colspan="22" |Gram-Positive Bacteria
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|-
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|[[Staphylococcus aureus]]
  +
|
  +
|
  +
|PBP2
  +
''pbp2''
  +
|
  +
|
  +
|
  +
|MGT
  +
''mgt''
  +
|PBP2a
  +
''mecA''
  +
|
  +
|
  +
|PBP1
  +
''pbpA''
  +
|PBP3
  +
''pbp3''
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|PBP4
  +
''pbp4''
  +
|
  +
  +
|
  +
|-
  +
|[[Listeria monocytogenes]]
  +
|
  +
|
  +
|PBP1
  +
|PBP4
  +
|
  +
|
  +
|
  +
|PBP
  +
|
  +
|
  +
|PBP2
  +
|PBP3
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|PBP5
  +
|
  +
|
  +
|-
  +
|[[Enterococcus faecalis]]
  +
|
  +
|
  +
|PBP1a
  +
|PBP2a
  +
|PBP1b
  +
|
  +
|
  +
|PBP4
  +
|
  +
|
  +
|PBP2
  +
|PBP2b
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|DacF
  +
|
  +
|
  +
|-
  +
|[[Streptococcus pneumoniae]]
  +
|
  +
|
  +
|PBP1a
  +
''pbpA''
  +
|PBP2a
  +
''pbp2&''
  +
|PBP1b
  +
''pbp1b''
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|PBP2x
  +
''pvpX''
  +
|PBP2b
  +
''pbp2b''
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|
  +
|PBP3
  +
''pbp3''
  +
|
  +
|
  +
|-
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! colspan="22" |Other Bacteria
  +
|-
  +
|[[Mycobacterium tuberculosis]]
  +
|
  +
|
  +
|
  +
|PBP1
  +
''ponA1''
  +
|
  +
|
  +
|PBP1A (r)
  +
''ponA2''
  +
|
  +
|PBPA
  +
''pbpA''
  +
|
  +
|PBP2
  +
''pbpB''
  +
|
  +
|
  +
|
  +
|
  +
|PBP-lipo
  +
''Rv2864c''
  +
|
  +
|PBP4
  +
''Rv3627''
  +
|PBP5
  +
''dacB1''
  +
|PBP7
  +
''dacB2''
  +
|PBP
  +
|}
  +
  +
== PBP Mutations ==
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  +
* [[Escherichia coli]]: PBP3 insert (YRIN/YRIK)
  +
* [[Klebsiella pneumoniae]]: PBP1, PBP2, and PBP3
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* [[Pseudomonas aeruginosa]]: PBP1 and PBP3
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* [[Acinetobacter baumannii]]: PHP3-H370Y, PBP3-Q488K and Y528H
  +
  +
== Antibiotic Targets ==
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  +
* MSSA
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** Cefazolin: primarily PBP2, but all except PBP4
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** Ertapenem: PBP1
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** Cefaclor: PBP3
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** Cefoxitin: PBP4
   
−
<br />
  
 
[[Category:Infectious diseases]]
  
[[Category:Infectious diseases]]
 
[[Category:Microbiology]]
  
[[Category:Microbiology]]

Latest revision as of 12:46, 20 July 2023

  • A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure
Class A Class B Class C
A1 A2 A3 A4 A5 A6 A7 B1 B2 B3 B4 B5 B5 B6 B-like-I B-like-II B-like-III Type-4 Type-5 Type-7 Type-AmpH
Gram-Negative Bacteria
Escherichia coli PBP1a

ponA

PBP1b

ponB

PBP1c

pbpC

MGT

mgt

PHP2

pbpA

PHP3

ftsI

PBP4

dacB

PBP5, PHP6, PHP6b

dacA, dacC, dacD

PBP7

pbpG

PBP4b, AmpH

yefw, ampH

Neisseria gonorrhoeae PBP1

ponA

PBP2

ftsI

PBP3

pbp3

PBP4

pbp4

Gram-Positive Bacteria
Staphylococcus aureus PBP2

pbp2

MGT

mgt

PBP2a

mecA

PBP1

pbpA

PBP3

pbp3

PBP4

pbp4

Listeria monocytogenes PBP1 PBP4 PBP PBP2 PBP3 PBP5
Enterococcus faecalis PBP1a PBP2a PBP1b PBP4 PBP2 PBP2b DacF
Streptococcus pneumoniae PBP1a

pbpA

PBP2a

pbp2&

PBP1b

pbp1b

PBP2x

pvpX

PBP2b

pbp2b

PBP3

pbp3

Other Bacteria
Mycobacterium tuberculosis PBP1

ponA1

PBP1A (r)

ponA2

PBPA

pbpA

PBP2

pbpB

PBP-lipo

Rv2864c

PBP4

Rv3627

PBP5

dacB1

PBP7

dacB2

PBP

PBP Mutations

Antibiotic Targets

  • MSSA
    • Cefazolin: primarily PBP2, but all except PBP4
    • Ertapenem: PBP1
    • Cefaclor: PBP3
    • Cefoxitin: PBP4
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