Penicillin-binding protein: Difference between revisions
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(Created page with "* A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure <br /> Ca...") |
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+ | *A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure |
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+ | {| class="wikitable" |
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+ | ! rowspan="2" | |
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+ | ! colspan="7" |Class A |
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+ | ! colspan="10" |Class B |
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+ | ! colspan="4" |Class C |
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+ | |- |
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+ | !A1 |
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+ | !A2 |
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+ | !A3 |
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+ | !A4 |
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+ | !A5 |
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+ | !A6 |
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+ | !A7 |
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+ | !B1 |
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+ | !B2 |
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+ | !B3 |
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+ | !B4 |
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+ | !B5 |
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+ | !B5 |
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+ | !B6 |
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+ | !B-like-I |
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+ | !B-like-II |
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+ | !B-like-III |
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+ | !Type-4 |
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+ | !Type-5 |
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+ | !Type-7 |
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+ | !Type-AmpH |
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+ | |- |
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+ | ! colspan="22" |Gram-Negative Bacteria |
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+ | |- |
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+ | |[[Escherichia coli]] |
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+ | |PBP1a |
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+ | ''ponA'' |
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+ | |PBP1b |
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+ | ''ponB'' |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP1c |
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+ | ''pbpC'' |
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+ | |MGT |
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+ | ''mgt'' |
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+ | | |
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+ | |PHP2 |
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+ | ''pbpA'' |
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+ | |PHP3 |
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+ | ''ftsI'' |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP4 |
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+ | ''dacB'' |
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+ | |PBP5, PHP6, PHP6b |
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+ | ''dacA, dacC, dacD'' |
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+ | |PBP7 |
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+ | ''pbpG'' |
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+ | |PBP4b, AmpH |
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+ | ''yefw, ampH'' |
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+ | |- |
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+ | |[[Neisseria gonorrhoeae]] |
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+ | |PBP1 |
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+ | ''ponA'' |
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+ | | |
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+ | |||
+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP2 |
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+ | ''ftsI'' |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP3 |
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+ | ''pbp3'' |
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+ | | |
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+ | |PBP4 |
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+ | ''pbp4'' |
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+ | | |
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+ | |- |
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+ | ! colspan="22" |Gram-Positive Bacteria |
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+ | |- |
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+ | |[[Staphylococcus aureus]] |
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+ | | |
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+ | | |
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+ | |PBP2 |
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+ | ''pbp2'' |
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+ | | |
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+ | | |
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+ | | |
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+ | |MGT |
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+ | ''mgt'' |
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+ | |PBP2a |
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+ | ''mecA'' |
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+ | | |
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+ | | |
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+ | |PBP1 |
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+ | ''pbpA'' |
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+ | |PBP3 |
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+ | ''pbp3'' |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP4 |
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+ | ''pbp4'' |
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+ | | |
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+ | |||
+ | | |
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+ | |- |
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+ | |[[Listeria monocytogenes]] |
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+ | | |
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+ | | |
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+ | |PBP1 |
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+ | |PBP4 |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP |
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+ | | |
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+ | | |
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+ | |PBP2 |
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+ | |PBP3 |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP5 |
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+ | | |
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+ | | |
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+ | |- |
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+ | |[[Enterococcus faecalis]] |
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+ | | |
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+ | | |
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+ | |PBP1a |
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+ | |PBP2a |
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+ | |PBP1b |
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+ | | |
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+ | | |
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+ | |PBP4 |
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+ | | |
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+ | | |
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+ | |PBP2 |
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+ | |PBP2b |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |DacF |
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+ | | |
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+ | | |
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+ | |- |
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+ | |[[Streptococcus pneumoniae]] |
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+ | | |
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+ | | |
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+ | |PBP1a |
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+ | ''pbpA'' |
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+ | |PBP2a |
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+ | ''pbp2&'' |
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+ | |PBP1b |
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+ | ''pbp1b'' |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP2x |
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+ | ''pvpX'' |
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+ | |PBP2b |
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+ | ''pbp2b'' |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP3 |
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+ | ''pbp3'' |
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+ | | |
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+ | | |
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+ | |- |
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+ | ! colspan="22" |Other Bacteria |
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+ | |- |
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+ | |[[Mycobacterium tuberculosis]] |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP1 |
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+ | ''ponA1'' |
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+ | | |
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+ | | |
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+ | |PBP1A (r) |
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+ | ''ponA2'' |
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+ | | |
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+ | |PBPA |
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+ | ''pbpA'' |
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+ | | |
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+ | |PBP2 |
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+ | ''pbpB'' |
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+ | | |
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+ | | |
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+ | | |
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+ | | |
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+ | |PBP-lipo |
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+ | ''Rv2864c'' |
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+ | | |
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+ | |PBP4 |
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+ | ''Rv3627'' |
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+ | |PBP5 |
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+ | ''dacB1'' |
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+ | |PBP7 |
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+ | ''dacB2'' |
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+ | |PBP |
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+ | |} |
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+ | |||
+ | == PBP Mutations == |
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+ | |||
+ | * [[Escherichia coli]]: PBP3 insert (YRIN/YRIK) |
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+ | * [[Klebsiella pneumoniae]]: PBP1, PBP2, and PBP3 |
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+ | * [[Pseudomonas aeruginosa]]: PBP1 and PBP3 |
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+ | * [[Acinetobacter baumannii]]: PHP3-H370Y, PBP3-Q488K and Y528H |
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+ | |||
+ | == Antibiotic Targets == |
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+ | |||
+ | * MSSA |
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+ | ** Cefazolin: primarily PBP2, but all except PBP4 |
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+ | ** Ertapenem: PBP1 |
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+ | ** Cefaclor: PBP3 |
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+ | ** Cefoxitin: PBP4 |
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− | <br /> |
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[[Category:Infectious diseases]] |
[[Category:Infectious diseases]] |
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[[Category:Microbiology]] |
[[Category:Microbiology]] |
Latest revision as of 12:46, 20 July 2023
- A group of enzymes including transpeptidases, carboxypeptidases, and endopeptidases that play a role in the formation and maintenance of the cell wall structure
Class A | Class B | Class C | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A1 | A2 | A3 | A4 | A5 | A6 | A7 | B1 | B2 | B3 | B4 | B5 | B5 | B6 | B-like-I | B-like-II | B-like-III | Type-4 | Type-5 | Type-7 | Type-AmpH | |
Gram-Negative Bacteria | |||||||||||||||||||||
Escherichia coli | PBP1a
ponA |
PBP1b
ponB |
PBP1c
pbpC |
MGT
mgt |
PHP2
pbpA |
PHP3
ftsI |
PBP4
dacB |
PBP5, PHP6, PHP6b
dacA, dacC, dacD |
PBP7
pbpG |
PBP4b, AmpH
yefw, ampH | |||||||||||
Neisseria gonorrhoeae | PBP1
ponA |
PBP2
ftsI |
PBP3
pbp3 |
PBP4
pbp4 |
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Gram-Positive Bacteria | |||||||||||||||||||||
Staphylococcus aureus | PBP2
pbp2 |
MGT
mgt |
PBP2a
mecA |
PBP1
pbpA |
PBP3
pbp3 |
PBP4
pbp4 |
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Listeria monocytogenes | PBP1 | PBP4 | PBP | PBP2 | PBP3 | PBP5 | |||||||||||||||
Enterococcus faecalis | PBP1a | PBP2a | PBP1b | PBP4 | PBP2 | PBP2b | DacF | ||||||||||||||
Streptococcus pneumoniae | PBP1a
pbpA |
PBP2a
pbp2& |
PBP1b
pbp1b |
PBP2x
pvpX |
PBP2b
pbp2b |
PBP3
pbp3 |
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Other Bacteria | |||||||||||||||||||||
Mycobacterium tuberculosis | PBP1
ponA1 |
PBP1A (r)
ponA2 |
PBPA
pbpA |
PBP2
pbpB |
PBP-lipo
Rv2864c |
PBP4
Rv3627 |
PBP5
dacB1 |
PBP7
dacB2 |
PBP |
PBP Mutations
- Escherichia coli: PBP3 insert (YRIN/YRIK)
- Klebsiella pneumoniae: PBP1, PBP2, and PBP3
- Pseudomonas aeruginosa: PBP1 and PBP3
- Acinetobacter baumannii: PHP3-H370Y, PBP3-Q488K and Y528H
Antibiotic Targets
- MSSA
- Cefazolin: primarily PBP2, but all except PBP4
- Ertapenem: PBP1
- Cefaclor: PBP3
- Cefoxitin: PBP4