Opioid use disorder: Difference between revisions

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*A [[substance use disorder]] involving heroin, fentanyl, or other opioid medications
*A [[substance use disorder]] involving heroin, fentanyl, or other opioid medications
*For reference, 1 point of street fentanyl is 100 mg, which is usually 4.4 mg of pure fentanyl


===Epidemiology===
===Epidemiology===
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*Slow-release opioids such as [[Kadian]] third-line
*Slow-release opioids such as [[Kadian]] third-line


== Prevention ==
==Prevention==


* Follow safe prescribing practices
*Follow safe prescribing practices
* Risk assessment
*Risk assessment
** Consider their personal and family history of psychiatric illness and substance use disorder
**Consider their personal and family history of psychiatric illness and substance use disorder
** Consider their social history, including their living situation, safety of housing, personal safety, children or dependents, and social supports
**Consider their social history, including their living situation, safety of housing, personal safety, children or dependents, and social supports
** Can use tools such as the [[opioid risk tool]] or [[SOAPP-R]] as a more formal risk assessment
**Can use tools such as the [[opioid risk tool]] or [[SOAPP-R]] as a more formal risk assessment
**Physical exam, looking for signs of substance use and its complications
**Bloodwork, including liver function tests, hemoglobin, and MCV


==Further Reading==
==Further Reading==


*Management of opioid use disorders: a national clinical practice guideline. ''CMAJ''. 2018;190(9):e247-e257. doi: [https://doi.org/10.1503/cmaj.170958 10.1503/cmaj.170958]
*Management of opioid use disorders: a national clinical practice guideline. ''CMAJ''. 2018;190(9):e247-e257. doi: [https://doi.org/10.1503/cmaj.170958 10.1503/cmaj.170958]
*Opioid Agonist Therapy:A Synthesis of Canadian Guidelines for Treating Opioid Use Disorder. 2021. Available at: https://www.camh.ca/-/media/files/professionals/canadian-opioid-use-disorder-guideline2021-pdf.pdf


[[Category:Addiction medicine]]
[[Category:Addiction medicine]]

Latest revision as of 18:59, 24 October 2021

Background

  • A substance use disorder involving heroin, fentanyl, or other opioid medications
  • For reference, 1 point of street fentanyl is 100 mg, which is usually 4.4 mg of pure fentanyl

Epidemiology

  • The risk of OUD among patients treated with opioids for chronic pain is around 8 to 30%

Management

  • Precipitated withdrawal more dangerous than natural withdrawal

Acute Overdose

  • First give boluses of naloxone 0.04mg to 0.08mg IV to improve respiratory depression escalated quickly q2-3 minutes up to 0.4, 2, 4, 10, 15mg (start low and go fast)
  • Then start infusion of 2/3 the effective dose per hour
  • QRS and QT lengthening by blocking Na and K channels
    • May need repeated defibrillation, overdrive pacing, or ECMO

Opioid Substitution Therapy (OST)

Prevention

  • Follow safe prescribing practices
  • Risk assessment
    • Consider their personal and family history of psychiatric illness and substance use disorder
    • Consider their social history, including their living situation, safety of housing, personal safety, children or dependents, and social supports
    • Can use tools such as the opioid risk tool or SOAPP-R as a more formal risk assessment
    • Physical exam, looking for signs of substance use and its complications
    • Bloodwork, including liver function tests, hemoglobin, and MCV

Further Reading