Acquired immunodeficiency: Difference between revisions
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* See also [[immunodeficiency]] and [[primary immunodeficiency]] |
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==Clinical Manifestations== |
==Clinical Manifestations== |
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{| class="wikitable" |
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* See also [[Immunodeficiency#Clinical%20Manifestations|clinical manifestations of immunodeficiency]] |
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!Immune Defect |
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!Typical Infections |
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!Typical Organisms |
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|cell-mediated (T cells) |
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|persistent viral infections, opportunistic infections, disseminated infections |
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|[[Pneumocystis jirovecii]], [[Cryptococcus]], [[Herpesviridae]] |
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|humoural (B cells) |
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|respiratory infections with [[Encapsulated bacteria|encapsulated organisms]], [[chronic diarrhea]], [[aseptic meningitis]] |
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|[[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Giardia lamblia]], [[Campylobacter species]], [[Enterovirus|enteroviruses]] |
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|phagocytic |
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|recurrent [[Abscess|abscesses]], [[gingivitis]], [[Aphthous ulcer|aphthous ulcers]] |
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|[[Staphylococcus aureus]], [[Burkholderia cepacia]], [[Serratia marcescens]], [[Aspergillus species]], [[Nocardia species]] |
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|monocytic |
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|disseminated infections and multifocal [[osteomyelitis]] |
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|[[non-tuberculous mycobacteria]], [[Salmonella species]], [[Histoplasma capsulatum]], [[Coccidioides immitis]] |
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|[[Toll-like receptors|TLR]] |
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|recurrent [[meningitis]], [[bacteremia]], absence of fever |
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|[[Streptococcus pneumoniae]], [[Neisseria meningitidis]], [[Staphylococcus aureus]], [[HSV]] |
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|complement |
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|recurrent [[bacteremia]] and [[meningitis]] |
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|[[Neisseria species]] |
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|T cells and phagocytes |
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|[[eczema]], [[kyphoscoliosis]], pathologic fratures, pulmonary and cutaneous infections, [[mucocutaneous candidiasis]] |
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|[[Staphylococcus aureus]], [[Haemophilus influenzae]], [[Streptococcus pneumoniae]], [[Candida albicans]] |
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==Differential Diagnosis== |
==Differential Diagnosis== |
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*[[Multiple myeloma]] and [[chronic lymphocytic leukemia]] |
*[[Multiple myeloma]] and [[chronic lymphocytic leukemia]] |
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===Phagocytic Defect=== |
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*[[Corticosteroids]] |
*[[Corticosteroids]] |
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Latest revision as of 00:08, 16 February 2023
- See also immunodeficiency and primary immunodeficiency
Clinical Manifestations
Differential Diagnosis
Cell-Mediated Immunodeficiency
- Corticosteroids
- Solid organ transplantation
- Hematologic malignancy
- Chemotherapy
- Human immunodeficiency virus
Humoural Immunodeficiency
- Splenectomy and asplenism
- Complement deficiency
- Common variable immunodeficiency
- Rituximab and other anti-CD20 therapy
- Multiple myeloma and chronic lymphocytic leukemia
