Inflammatory bowel disease: Difference between revisions

Latest revision as of 19:22, 19 February 2022

	Ulcerative colitis	Crohn disease
Location	Pancolitis (30%) Proctosigmoiditis (50%) Includes PSC (5%)	Terminal ileum (80%) Ileocolonic (50%) Isolated ileal (30%) Isolated colonic (20%)
Distribution	Continuous from rectum	Skip lesions, often rectum-sparing
Histology	Mucosal inflammation without granulomas	Transmural inflammation, granulomas, cobblestone
Serology	p-ANCA	Anti-Saccharomyces cervisiae IgG
Complications	Toxic megacolon Colorectal cancer	Intraabdominal abscess, perforation, fistulae, strictures, perianal disease, obstruction, colorectal cancer

Infectious mimics (see below)
Radiation colitis
Diversion colitis
Solitary rectal ulcer syndrome
Graft versus host disease
Diverticular colitis
Medication-induced colitis, including NSAIDs, retinoic acid, checkpoint inhibitors, mycophenolate, and gold
CVID

@@ Line 63: / Line 63: @@
 *Months to years
 *Independent of disease activity
+== Differential Diagnosis ==
+* Infectious mimics (see below)
+* Radiation colitis
+* Diversion colitis
+* Solitary rectal ulcer syndrome
+* Graft versus host disease
+* Diverticular colitis
+* Medication-induced colitis, including [[NSAIDs]], retinoic acid, checkpoint inhibitors, [[mycophenolate]], and [[gold]]
+* [[CVID]]
+=== Colitis or Ileitis ===
+* Bacterial: [[Shigella]], enterohemorrhagic [[Escherichia coli]], enteroinvasive [[Escherichia coli]], [[Campylobacter jejuni]], [[Salmonella]], [[Yersinia enterocolitica]], [[Mycobacterium tuberculosis]], [[Clostridioides difficile]], [[Vibrio parahaemolyticus]], [[Chlamydia trachomatis]] ([[lymphogranuloma venereum]])
+* Parasitic: [[Entamoeba histolytica]], [[Schistosoma]], [[Balantidium coli]], [[Trichinella spiralis]]
+* Viruses: [[cytomegalovirus]]
+=== Proctitis ===
+* [[Neisseria gonorrhoeae]]
+* [[Herpes simplex virus]]
+* [[Chlamydia trachomatis]]
+* [[Treponema pallidum]]
+* [[Cytomegalovirus]]
 [[Category:Gastroenterology]]