Clostridium perfringens: Difference between revisions
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Clostridium perfringens
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== Background == |
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===Microbiology=== |
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*Often encapsulated short Gram-variable bacilli of varying length |
*Often encapsulated short Gram-variable bacilli of varying length |
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**Type B & D: no disease in humans |
**Type B & D: no disease in humans |
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== Management == |
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* For gas gangrene, typically requires surgical debridement and [[penicillin G]] |
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** Consider adding [[clindamycin]] for theoretical decreased toxin production in [[toxic shock syndrome]] |
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* Otherwise, generally susceptible to [[erythromycin]], [[chloramphenicol]], [[cefazolin]], [[cefoxitin]], [[ceftriaxone]], [[piperacillin]], [[carbapenems]], [[metronidazole]], [[vancomycin]], and [[linezolid]] |
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{{DISPLAYTITLE:''Clostridium perfringens''}} |
{{DISPLAYTITLE:''Clostridium perfringens''}} |
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[[Category:Gram-positive bacilli]] |
[[Category:Gram-positive bacilli]] |
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Revision as of 16:46, 14 December 2021
Background
Microbiology
- Often encapsulated short Gram-variable bacilli of varying length
- Found in soil and humans and animals intestines
- Makes necrotizing extracellular toxins
- Four types:
- Type A: foodborne outbreaks associated with poorly heated food and meat; gas gangrene in patients with necrotic bowel
- Type C: pork product ingestion followed by enteritis necroticans (hemorrhagic necrosis of the jejunum)
- Type B & D: no disease in humans
Management
- For gas gangrene, typically requires surgical debridement and penicillin G
- Consider adding clindamycin for theoretical decreased toxin production in toxic shock syndrome
- Otherwise, generally susceptible to erythromycin, chloramphenicol, cefazolin, cefoxitin, ceftriaxone, piperacillin, carbapenems, metronidazole, vancomycin, and linezolid
