Clostridium septicum: Difference between revisions

Latest revision as of 09:49, 15 October 2020

Background

Microbiology

Gram-positive bacillus
Member of the genus Clostridium
Produces alpha toxin, which lyses neutrophils

Risk factors

Associated with colon cancer or neutropenia
Diabetes also a risk factor

Clinical Manifestations

Can cause bacteremia and non-traumatic myonecrosis
Clinical presentation is typically fulminant sepsis, which very high mortality

Management

Aggressive surgical debridement, possibly including amputation
Broad-spectrum antibiotics for necrotizing fasciitis are indicated until the microbiologic diagnosis is confirmed
First-line antimicrobials are penicillin 2-4 million units IV q4h plus clindamycin 600-900 mg IV q6h

@@ Line 1: / Line 1: @@
-== Background ==
+==Background==
-=== Microbiology ===
+===Microbiology===
-* [[Stain::Gram-positive]] [[Cellular shape::bacillus]]
-* Member of the genus ''[[Clostridium species|Clostridium]]''
-* Produces alpha toxin
+*[[Stain::Gram-positive]] [[Shape::bacillus]]
-=== Risk factors ===
+*Member of the genus ''[[Clostridium species|Clostridium]]''
-* Associated with colon cancer or neutropenia
+*Produces alpha toxin, which lyses neutrophils
-* Diabetes also a risk factor
+===Risk factors===
-== Clinical Manifestations ==
-* Can cause bacteremia and non-traumatic myonecrosis
-* Clinical presentation is typically fulminant sepsis, which very high mortality
+*Associated with [[colon cancer]] or [[neutropenia]]
-== Management ==
+*[[Diabetes]] also a risk factor
-* Aggressive surgical debridement, possibly including amputation
-* Broad-spectrum antibiotics for [[necrotizing fasciitis]] are indicated until the microbiologic diagnosis is confirmed
+==Clinical Manifestations==
-* First-line antimicrobials are [[Is treated by::penicillin]] 2-4 million units IV q4h plus [[Is treated by::clindamycin]] 600-900 mg IV q6h
+*Can cause bacteremia and non-traumatic myonecrosis
+*Clinical presentation is typically fulminant sepsis, which very high mortality
+==Management==
+*Aggressive surgical debridement, possibly including amputation
+*Broad-spectrum antibiotics for [[necrotizing fasciitis]] are indicated until the microbiologic diagnosis is confirmed
+*First-line antimicrobials are [[Is treated by::penicillin]] 2-4 million units IV q4h plus [[Is treated by::clindamycin]] 600-900 mg IV q6h
 {{DISPLAYTITLE:''Clostridium septicum''}}