Β-lactam resistance: Difference between revisions

Revision as of 07:06, 3 September 2020

Based on amino acid sequences rather than function
Classes A, C, and D are serine ß-lactamases, while class B are metallo-β-lactamases


Ambler	Binding Site	Examples	Inhibitors
A	serine	TEM, SHV, KPC, CTX-M, GES	avibactam, vaborbactam, relebactam
B	metallo	VIM, NDM, IMP
C	serine	AmpC, P99	avibactam, vaborbactam, relebactam
D	serine	OXA (oxacillinase) enzymes	avibactam (OXA-48)

Major cause of resistance in Pseudomonas aeruginosa and similar species
e.g. MexAB-OprM, which confers broad antimicrobial resistance including cephalosporins and some carbapanems

@@ Line 13: / Line 13: @@
 *Based on amino acid sequences rather than function
-*Classes A, C, and D are serine ß-lactamases
+*Classes A, C, and D are serine ß-lactamases, while class B are metallo-β-lactamases
-*'''Class A:''' original active-site serine ß-lactamases
-*'''Class B:''' original metallo-ß-lactamases
-*'''Class C:''' AmpC ß-lactamases
-*'''Class D:''' OXA ß-lactamases
+{| class="wikitable"
+|+
+!Ambler
+!Binding Site
+!Examples
+!Inhibitors
+|-
+|A
+|serine
+|TEM, SHV, KPC, CTX-M, GES
+|avibactam, vaborbactam, relebactam
+|-
+|B
+|metallo
+|VIM, NDM, IMP
+|
+|-
+|C
+|serine
+|AmpC, P99
+|avibactam, vaborbactam, relebactam
+|-
+|D
+|serine
+|OXA (oxacillinase) enzymes
+|avibactam (OXA-48)
+|}
+<br />
 ===Specific ß-lactamases===
 ====NDM-1====
 *Broad-spectrum metallo-beta-lactamase and carbapenemase
-*Can be treated empirically with [[ceftazidime-avibactam]] and [[aztreonam]] +/- [[colistin]]
 ==Efflux Pumps==