Tissue penetration of antimicrobials: Difference between revisions
From IDWiki
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
!CNS |
!CNS |
||
!Urine |
!Urine |
||
!Prostate |
|||
!Necrotic |
!Necrotic |
||
|- |
|- |
||
! colspan=" |
! colspan="7" |Antibiotics: β-Lactams |
||
|- |
|- |
||
| rowspan="2" |Penicillins |
| rowspan="2" |Penicillins |
||
|β-lactamase inhibitors |
|β-lactamase inhibitors |
||
| |
| |
||
| |
|– |
||
| ⚫ | |||
| |
| |
||
| |
| |
||
| Line 18: | Line 20: | ||
|[[ampicillin]] |
|[[ampicillin]] |
||
| |
| |
||
| |
| + |
||
| |
| |
||
| |
| |
||
|– |
|||
|- |
|- |
||
| rowspan="4" |Cephalosporins |
| rowspan="4" |Cephalosporins |
||
|first-generation cephalosporins |
|first-generation cephalosporins |
||
| |
| |
||
| |
|– |
||
| |
|||
| |
| |
||
| |
|– |
||
|- |
|- |
||
|second-generation cephalosporins |
|second-generation cephalosporins |
||
| |
| |
||
| |
|– |
||
| |
|||
| |
| |
||
| |
| |
||
| Line 39: | Line 44: | ||
| |
| |
||
| |
| |
||
| |
| |
||
| + |
|||
|- |
|- |
||
|[[ceftazidime]] |
|[[ceftazidime]] |
||
| |
| |
||
| |
| + |
||
| |
| |
||
| |
| |
||
| + |
|||
|- |
|- |
||
| rowspan="2" |Cephamycins |
| rowspan="2" |Cephamycins |
||
|[[cephamycins]] |
|[[cephamycins]] |
||
| |
| |
||
| |
|– |
||
| |
|||
| |
| |
||
| |
| |
||
| Line 58: | Line 66: | ||
| |
| |
||
| |
| |
||
| |
| |
||
|– |
|||
|- |
|- |
||
|Carbapenems |
|Carbapenems |
||
| Line 65: | Line 74: | ||
| |
| |
||
| |
| |
||
| |
| |
||
| + |
|||
|- |
|||
! colspan="7" |Antibiotics: Non-β-Lactams |
|||
|- |
|- |
||
|Aminoglycosides |
|Aminoglycosides |
||
| Line 72: | Line 84: | ||
| |
| |
||
| |
| |
||
| |
| |
||
|– |
|||
|- |
|||
| ⚫ | |||
|[[chloramphenicol]] |
|||
| |
|||
| |
|||
| |
|||
| |
|||
| + |
|||
|- |
|- |
||
|Fluoroquinolones |
|Fluoroquinolones |
||
| |
| |
||
| |
| |
||
| |
|–? |
||
| |
| |
||
| |
| + |
||
| + |
|||
|- |
|- |
||
|Lincosamides |
|Lincosamides |
||
|[[clindamycin]] |
|[[clindamycin]] |
||
| |
| |
||
| |
|– |
||
| |
| |
||
| |
| |
||
| + |
|||
|- |
|- |
||
|Macrolides |
|Macrolides |
||
|[[macrolides]] |
|||
| |
| |
||
|– |
|||
| |
| |
||
| |
| + |
||
| ⚫ | |||
| |
| |
||
|- |
|||
|Nitrofurans |
|||
|[[nitrofurantoin]] |
|||
|– |
|||
|– |
|||
| + |
|||
|– |
|||
|– |
|||
|- |
|- |
||
|Nitroimidazoles |
|Nitroimidazoles |
||
| Line 100: | Line 132: | ||
| |
| |
||
| |
| |
||
| |
| |
||
| + |
|||
|- |
|- |
||
|Rifamycins |
|||
| ⚫ | |||
|[[ |
|[[rifampin]] |
||
| |
| |
||
|NO |
|||
| |
| |
||
| |
|||
| + |
|||
| |
| |
||
|- |
|- |
||
|Sulfonamides |
|||
| ⚫ | |||
|[[sulfamethoxazole]] |
|||
| |
| |
||
| |
| |
||
| |
| |
||
| |
|– |
||
| |
|||
|- |
|- |
||
| ⚫ | |||
| ⚫ | |||
|[[ |
|[[tetracyclines]] |
||
| |
| |
||
|– |
|||
| |
| |
||
| + |
|||
| |
| |
||
|YES |
|||
|- |
|- |
||
| ⚫ | |||
| ⚫ | |||
| |
|||
| |
|||
| |
|||
| |
|||
| + |
|||
|- |
|||
| ⚫ | |||
|- |
|- |
||
|Azoles |
|Azoles |
||
| Line 129: | Line 173: | ||
| |
| |
||
| |
| |
||
| |
| |
||
| + |
|||
|} |
|} |
||
[[Category:Antimicrobials]] |
[[Category:Antimicrobials]] |
||
Revision as of 16:16, 24 August 2020
| Class | Antimicrobial | Blood | CNS | Urine | Prostate | Necrotic |
|---|---|---|---|---|---|---|
| Antibiotics: β-Lactams | ||||||
| Penicillins | β-lactamase inhibitors | – | ||||
| ampicillin | + | – | ||||
| Cephalosporins | first-generation cephalosporins | – | – | |||
| second-generation cephalosporins | – | |||||
| cefepime | + | |||||
| ceftazidime | + | + | ||||
| Cephamycins | cephamycins | – | ||||
| cefoxitin | – | |||||
| Carbapenems | imipenem | + | ||||
| Antibiotics: Non-β-Lactams | ||||||
| Aminoglycosides | – | |||||
| Chloramphenicol | chloramphenicol | + | ||||
| Fluoroquinolones | –? | + | + | |||
| Lincosamides | clindamycin | – | + | |||
| Macrolides | macrolides | – | + | |||
| Nitrofurans | nitrofurantoin | – | – | + | – | – |
| Nitroimidazoles | metronidazole | + | ||||
| Rifamycins | rifampin | + | ||||
| Sulfonamides | sulfamethoxazole | – | ||||
| Tetracyclines | tetracyclines | – | + | |||
| doxycycline | + | |||||
| Antifungals | ||||||
| Azoles | fluconazole | + | ||||
References
- ^ nau2010pe
- ^ Cornelia B. Landersdorfer, Jürgen B. Bulitta, Martina Kinzig, Ulrike Holzgrabe, Fritz Sörgel. Penetration of Antibacterials into Bone. Clinical Pharmacokinetics. 2009;48(2):89-124. doi:10.2165/00003088-200948020-00002.
- a b c d e f g h i j k l m n o p q r L. Brockhaus, D. Goldblum, L. Eggenschwiler, S. Zimmerli, C. Marzolini. Revisiting systemic treatment of bacterial endophthalmitis: a review of intravitreal penetration of systemic antibiotics. Clinical Microbiology and Infection. 2019;25(11):1364-1369. doi:10.1016/j.cmi.2019.01.017.
- a b Takashi Suzuki, Toshihiko Uno, Guangming Chen, Yuichi Ohashi. Ocular distribution of intravenously administered micafungin in rabbits. Journal of Infection and Chemotherapy. 2008;14(3):204-207. doi:10.1007/s10156-008-0612-5.
- a b c d e f g h Timothy Felton, Peter F. Troke, William W. Hope. Tissue Penetration of Antifungal Agents. Clinical Microbiology Reviews. 2014;27(1):68-88. doi:10.1128/cmr.00046-13.
- ^ Tony H. Huynh, Mark W. Johnson, Grant M. Comer, Douglas N. Fish. Vitreous Penetration of Orally Administered Valacyclovir. American Journal of Ophthalmology. 2008;145(4):682-686. doi:10.1016/j.ajo.2007.11.016.
- ^ Luis F. López-Cortés, R. Ruiz-Valderas, M. J. Lucero-Muñoz, E. Cordero, M. T. Pastor-Ramos, J. Marquez. Intravitreal, Retinal, and Central Nervous System Foscarnet Concentrations after Rapid Intravenous Administration to Rabbits. Antimicrobial Agents and Chemotherapy. 2000;44(3):756-759. doi:10.1128/aac.44.3.756-759.2000.
