Drug-induced lupus: Difference between revisions
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* High risk: |
* High risk: |
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** '''Hydralazine''' (antihypertensive) |
** '''[[Hydralazine]]''' (antihypertensive) |
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** Procainamide (antiarrhythmic) |
** [[Procainamide]] (antiarrhythmic) |
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* Moderate to low risk: |
* Moderate to low risk: |
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** Infliximab (anti-TNF-α) |
** [[Infliximab]] (anti-TNF-α) |
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** Etanercept (anti-TNF-α) |
** [[Etanercept]] (anti-TNF-α) |
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** Isoniazid (antibiotic) |
** [[Isoniazid]] (antibiotic) |
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** Minocycline (antibiotic) |
** [[Minocycline]] (antibiotic) |
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** Pyrazinamide (antibiotic) |
** [[Pyrazinamide]] (antibiotic) |
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** Quinidine (antiarrhythmic) |
** [[Quinidine]] (antiarrhythmic) |
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** D-penicillamine (anti-inflammatory) |
** [[D-penicillamine]] (anti-inflammatory) |
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** Carbamazepine (anticonvulsant) |
** [[Carbamazepine]] (anticonvulsant) |
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** Oxcarbazepine (anticonvulsant) |
** [[Oxcarbazepine]] (anticonvulsant) |
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** Phenytoin (anticonvulsant) |
** [[Phenytoin]] (anticonvulsant) |
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** Propafenone (antiarrhythmic) |
** [[Propafenone]] (antiarrhythmic) |
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** Chlorpromazine (antipsychotic) |
** [[Chlorpromazine]] (antipsychotic) |
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** Minoxidil (antihypertensive vasodilator) |
** [[Minoxidil]] (antihypertensive vasodilator) |
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== Investigations == |
== Investigations == |
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Latest revision as of 14:31, 15 April 2025
Definition
- Form of lupus that is caused by a drug reaction
Causative Medications
- High risk:
- Hydralazine (antihypertensive)
- Procainamide (antiarrhythmic)
- Moderate to low risk:
- Infliximab (anti-TNF-α)
- Etanercept (anti-TNF-α)
- Isoniazid (antibiotic)
- Minocycline (antibiotic)
- Pyrazinamide (antibiotic)
- Quinidine (antiarrhythmic)
- D-penicillamine (anti-inflammatory)
- Carbamazepine (anticonvulsant)
- Oxcarbazepine (anticonvulsant)
- Phenytoin (anticonvulsant)
- Propafenone (antiarrhythmic)
- Chlorpromazine (antipsychotic)
- Minoxidil (antihypertensive vasodilator)
Investigations
- Serology positive for anti-histone antibodies
Management
- Stop the offending medication
- Treat the symptoms similarly to how you would in lupus, until they resolve
- Arthralgia/arthritis/serositis: NSAIDs
- Cutaneous eruptions: topical steroids
- If prolonged symptoms: hydroxychloroquine
- Rarely steroids
