Corynebacterium: Difference between revisions
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Corynebacterium
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*Genus of [[Stain::Gram-positive]] club-shaped [[Shape::bacillus|bacilli]] that form characteristic "Chinese letter" patterns on stain |
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* Includes: |
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** [[Corynebacterium striatum]] |
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** [[Corynebacterium jeikeium]] |
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** [[Corynebacterium diphtheriae]] |
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** [[Corynebacterium pseudotuberculosis]] |
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** [[Corynebacterium amycolatum]] |
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** [[Corynebacterium urealyticum]] |
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{| class="wikitable" |
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{{DISPLAYTITLE:''Corynebacterium'' species}} |
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!Species |
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!Diseases |
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!Resistance |
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! colspan="3" |''Corynebacterium'' Species |
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|[[Corynebacterium afermentans]] subsp. ''afermentans'' |
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|[[CLABSI]] |
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|[[Corynebacterium amycolatum]] |
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|[[healthcare-associated pneumonia]], [[CLABSI]], [[native valve endocarditis]], [[prosthetic valve endocarditis]], [[skin and soft tissue infection]], [[surgical site infection]] |
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|[[Corynebacterium confusum]] |
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|[[skin and soft tissue infection]] |
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|[[Corynebacterium diphtheriae]] |
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|[[diphtheria]], [[myocarditis]] |
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|[[Corynebacterium glucuronolyticum]] |
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|[[genitourinary infection]], [[chronic prostatitis]] |
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|[[Corynebacterium jeikeium]] |
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|[[ventricular shunt infection]], nosocomial [[meningitis]], [[CLABSI]], [[native valve endocarditis]], [[prosthetic valve endocarditis]], [[surgical site infection]], [[prosthetic joint infection]], [[CAPD]] [[peritonitis]] |
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|mostly resistant to beta lactams, macrolides, and aminoglycosides |
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|[[Corynebacterium kroppenstedtii]] |
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|breast [[abscess]] |
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|[[Corynebacterium macginleyi]] |
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|[[conjunctivitis]], [[keratitis]], [[CLABSI]] |
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|[[Corynebacterium minutissimum]] |
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|[[skin and soft tissue infection]], breast [[abscess]], [[CLABSI]], [[surgical site infection]] |
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|[[Corynebacterium propinquum]] |
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|[[conjunctivitis]], [[keratitis]], [[native valve endocarditis]] |
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|[[Corynebacterium pseudodiphtheriticum]] |
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|[[conjunctivitis]], [[keratitis]], [[pharyngitis]], [[native valve endocarditis]], [[healthcare-associated pneumonia]] |
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|[[Corynebacterium pseudotuberculosis]] |
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|[[lymphadenitis]], [[skin and soft tissue infection]] |
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|may exhibit erm-mediated resistance to [[clindamycin]] and [[macrolides]] |
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|[[Corynebacterium riegelii]] |
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|[[genitourinary infection]] |
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|[[Corynebacterium striatum]] |
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|[[native joint infection]], [[healthcare-associated pneumonia]], [[CLABSI]], [[native valve endocarditis]], [[prosthetic valve endocarditis]], [[surgical site infection]] |
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|may exhibit erm-mediated resistance to [[clindamycin]] and [[macrolides]] |
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|[[Corynebacterium tuberculostearicum]] |
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|breast [[abscess]] |
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|[[Corynebacterium ulcerans]] |
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|[[diphtheria]], [[pharyngitis]], [[skin and soft tissue infection]] |
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|[[Corynebacterium urealyticum]] |
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|[[healthcare-associated pneumonia]], [[CLABSI]], [[native valve endocarditis]], [[skin and soft tissue infection]], [[surgical site infection]], [[UTI]], [[CAPD]] [[peritonitis]] |
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|mostly resistant to beta lactams, macrolides, and aminoglycosides |
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! colspan="3" |Other Coryneform Bacteria |
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|[[Arcanobacterium haemolyticum]] |
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|[[pharyngitis]], [[peritonsillar abscess]], [[odontogenic infection]], [[skin and soft tissue infection]], [[native valve endocarditis]] |
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|[[Brevibacterium]] |
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|nosocomial [[meningitis]], [[CAPD]] [[peritonitis]] |
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|[[Brevibacterium casei]] |
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|[[CLABSI]], [[prosthetic valve endocarditis]] |
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|[[Cellulosimicrobium]] |
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|[[Dermabacter]] |
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|[[CAPD]] [[peritonitis]] |
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|[[Microbacterium]] |
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|[[CLABSI]] |
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|[[Oerskovia]] |
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|[[CLABSI]] |
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|[[Rothia dentocariosa]] |
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|[[odontogenic infection]], [[native valve endocarditis]], [[CAPD]] [[peritonitis]] |
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|[[Trueperella bernardiae]] |
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|[[CLABSI]] |
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|[[Trueperella pyogenes]] |
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|[[skin and soft tissue infection]], [[CLABSI]] |
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|} |
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== Management == |
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* The only reliable treatment options are [[vancomycin]], [[daptomycin]], and [[linezolid]][[CiteRef::neemuchwala2018in]] |
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** [[Tetracycline]] and [[TMP-SMX]] are sometimes options depending on the species and isolate |
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** See also [[CiteRef::neemuchwala2018in]] for a recent summary of susceptibilities in Ontario |
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{| class="wikitable" |
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|+Susceptibilities (in %) in Ontario 2011-2016[[CiteRef::neemuchwala2018]] |
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!Species |
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![[Penicillin|PEN]] |
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![[Erythromycin|ERY]] |
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![[Clindamycin|CLI]] |
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![[Ciprofloxacin|CIP]] |
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![[Moxifloxacin|MXF]] |
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![[Tetracycline|TET]] |
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![[Vancomycin|VAN]] |
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![[Trimethoprim-sulfamethoxazole|SXT]] |
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![[Rifampin|RIF]] |
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![[Quinupristin-dalfopristin|Q-D]] |
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![[Linezolid|LZD]] |
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![[Gentamicin|GEN]] |
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![[Daptomycin|DAP]] |
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|- |
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|''Corynebacterium'' spp. |
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| style="color:darkred" |15 |
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| style="color:darkred" |15 |
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| style="color:darkred" |9 |
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| style="color:goldenrod" |27 |
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| style="color:goldenrod" |28 |
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| style="color:goldenrod" |64 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |38 |
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| style="color:darkgreen" |91 |
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| style="color:darkgreen" |93 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |93 |
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| style="color:darkgreen" |98 |
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|- |
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|[[Corynebacterium striatum]] |
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| style="color:darkred" |0.1 |
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| style="color:darkred" |15 |
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| style="color:darkred" |5 |
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| style="color:darkred" |5 |
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| style="color:darkred" |5 |
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| style="color:goldenrod" |35 |
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| style="color:darkgreen" |100 |
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| style="color:darkred" |12 |
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| style="color:goldenrod" |86 |
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| style="color:darkgreen" |99 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |93 |
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| style="color:darkgreen" |98 |
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|- |
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|[[Corynebacterium amycolatum]] |
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| style="color:darkred" |11 |
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| style="color:darkred" |16 |
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| style="color:goldenrod" |21 |
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| style="color:goldenrod" |27 |
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| style="color:goldenrod" |27 |
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| style="color:goldenrod" |86 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |67 |
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| style="color:darkgreen" |98 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |93 |
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| style="color:darkgreen" |100 |
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|- |
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|[[Corynebacterium pseudodiphtheriticum]]/[[Corynebacterium propinquum]] |
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| style="color:darkgreen" |96 |
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| style="color:goldenrod" |21 |
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| style="color:goldenrod" |21 |
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| style="color:goldenrod" |79 |
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| style="color:goldenrod" |79 |
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| style="color:darkgreen" |99 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |88 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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|- |
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|[[Corynebacterium afermentans]] subsp. afermentans |
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| style="color:darkred" |1 |
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| style="color:darkred" |0 |
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| style="color:darkred" |0 |
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| style="color:goldenrod" |30 |
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| style="color:goldenrod" |32 |
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| style="color:goldenrod" |88 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |55 |
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| style="color:darkgreen" |94 |
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| style="color:goldenrod" |52 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |99 |
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| style="color:darkgreen" |98 |
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|- |
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|[[Corynebacterium jeikeium]] |
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| style="color:darkred" |0 |
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| style="color:darkred" |12 |
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| style="color:darkred" |3 |
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| style="color:goldenrod" |36 |
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| style="color:goldenrod" |36 |
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| style="color:darkgreen" |92 |
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| style="color:darkgreen" |100 |
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| style="color:darkred" |18 |
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| style="color:darkgreen" |97 |
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| style="color:darkgreen" |90 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |82 |
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| style="color:darkgreen" |90 |
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|- |
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|[[Corynebacterium minutissimum]] |
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| style="color:darkred" |4 |
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| style="color:darkred" |20 |
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| style="color:darkred" |1 |
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| style="color:goldenrod" |55 |
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| style="color:goldenrod" |62 |
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| style="color:darkgreen" |92 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |62 |
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| style="color:darkgreen" |96 |
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| style="color:darkgreen" |93 |
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| style="color:darkgreen" |99 |
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| style="color:darkgreen" |97 |
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| style="color:darkgreen" |92 |
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|- |
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|[[Corynebacterium coyleae]] |
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| style="color:darkred" |2 |
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| style="color:darkred" |4 |
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| style="color:darkred" |4 |
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| style="color:goldenrod" |28 |
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| style="color:goldenrod" |29 |
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| style="color:darkgreen" |93 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |48 |
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| style="color:darkgreen" |91 |
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| style="color:goldenrod" |43 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |93 |
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|- |
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|[[Corynebacterium urealyticum]] |
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| style="color:darkred" |4 |
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| style="color:darkred" |2 |
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| style="color:darkred" |4 |
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| style="color:darkred" |4 |
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| style="color:darkred" |4 |
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| style="color:darkgreen" |92 |
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| style="color:darkgreen" |100 |
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| style="color:darkred" |2 |
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| style="color:darkgreen" |92 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |56 |
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| style="color:darkgreen" |100 |
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|[[Corynebacterium aurimucosum]] |
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| style="color:darkred" |6 |
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| style="color:darkred" |12 |
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| style="color:darkred" |0 |
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| style="color:goldenrod" |43 |
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| style="color:goldenrod" |43 |
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| style="color:darkgreen" |90 |
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| style="color:darkgreen" |100 |
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| style="color:goldenrod" |63 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |92 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |100 |
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| style="color:darkgreen" |98 |
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|} |
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{{DISPLAYTITLE:''Corynebacterium''}} |
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[[Category:Gram-positive bacilli]] |
[[Category:Gram-positive bacilli]] |
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Latest revision as of 18:18, 24 February 2025
- Genus of Gram-positive club-shaped bacilli that form characteristic "Chinese letter" patterns on stain
Management
- The only reliable treatment options are vancomycin, daptomycin, and linezolid1
- Tetracycline and TMP-SMX are sometimes options depending on the species and isolate
- See also 1 for a recent summary of susceptibilities in Ontario
| Species | PEN | ERY | CLI | CIP | MXF | TET | VAN | SXT | RIF | Q-D | LZD | GEN | DAP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Corynebacterium spp. | 15 | 15 | 9 | 27 | 28 | 64 | 100 | 38 | 91 | 93 | 100 | 93 | 98 |
| Corynebacterium striatum | 0.1 | 15 | 5 | 5 | 5 | 35 | 100 | 12 | 86 | 99 | 100 | 93 | 98 |
| Corynebacterium amycolatum | 11 | 16 | 21 | 27 | 27 | 86 | 100 | 67 | 98 | 100 | 100 | 93 | 100 |
| Corynebacterium pseudodiphtheriticum/Corynebacterium propinquum | 96 | 21 | 21 | 79 | 79 | 99 | 100 | 88 | 100 | 100 | 100 | 100 | 100 |
| Corynebacterium afermentans subsp. afermentans | 1 | 0 | 0 | 30 | 32 | 88 | 100 | 55 | 94 | 52 | 100 | 99 | 98 |
| Corynebacterium jeikeium | 0 | 12 | 3 | 36 | 36 | 92 | 100 | 18 | 97 | 90 | 100 | 82 | 90 |
| Corynebacterium minutissimum | 4 | 20 | 1 | 55 | 62 | 92 | 100 | 62 | 96 | 93 | 99 | 97 | 92 |
| Corynebacterium coyleae | 2 | 4 | 4 | 28 | 29 | 93 | 100 | 48 | 91 | 43 | 100 | 100 | 93 |
| Corynebacterium urealyticum | 4 | 2 | 4 | 4 | 4 | 92 | 100 | 2 | 92 | 100 | 100 | 56 | 100 |
| Corynebacterium aurimucosum | 6 | 12 | 0 | 43 | 43 | 90 | 100 | 63 | 100 | 92 | 100 | 100 | 98 |
